Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 6/20 | 0.48 |
| ▸ | PDE5A | O76074 | 4/20 | 0.47 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.46 |
| ▸ | MGAM | O43451 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | SI | P14410 | 1/20 | 0.46 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.46 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.46 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9635680 | 0.85 | AURKA (0.56) | AURKAPDE5APRMT5NPY5RPARP1 | |
| SCHEMBL9635658 | 0.85 | AURKA (0.56) | AURKAPDE5APRMT5NPY5RPARP1 | |
| SCHEMBL9634857 | 0.84 | PDE5A (0.55) | AURKAPDE5APRMT5NPY5R | |
| SCHEMBL9635725 | 0.84 | PDE5A (0.55) | AURKAPDE5APRMT5NPY5R | |
| SCHEMBL9634821 | 0.82 | PARP1 (0.49) | AURKAPDE5APRMT5HPSENPY5R | |
| SCHEMBL9634908 | 0.81 | PRMT5 (0.65) | AURKAPRMT5HPSEFAAHPARP1 | |
| SCHEMBL9635915 | 0.80 | AURKA (0.67) | AURKAPDE5APRMT5NPY5RFAAH | |
| SCHEMBL9634620 | 0.80 | PDE5A (0.52) | AURKAPDE5APRMT5 | |
| SCHEMBL9634834 | 0.79 | ALDH1A1 (0.44) | AURKAMGAMGAASIMGAM2 | |
| SCHEMBL9635685 | 0.78 | PDE5A (0.57) | AURKAPDE5APRMT5MGAMGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5104881-A | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-04-14 | — | — | US | disclosed |
| US-4616090-A | 2-arylimidazopyridines intermediates | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1986-10-07 | — | — | US | disclosed |
| EP-0072926-B1 | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GmbH (DE) | 1986-09-24 | — | — | EP | disclosed |
| EP-0072926-A1 | 2-Arylimidazopyridines | MERCK PATENT GmbH (DE) | 1983-03-02 | — | — | EP | disclosed |