Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 2/20 | 0.35 |
| ▸ | CKS1B | P61024 | 4/20 | 0.35 |
| ▸ | SKP2 | Q13309 | 4/20 | 0.35 |
| ▸ | GLO1 | Q04760 | 2/20 | 0.35 |
| ▸ | DHODH | Q02127 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | TOP2A | P11388 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.33 |
| ▸ | COMT | P21964 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2525466 | 0.85 | KDM4E (0.38) | TOP1CKS1BSKP2GLO1MMP2 | |
| SCHEMBL4356640 | 0.76 | TOP1 (0.41) | TOP1HPGDTOP2AALDH1A1MEN1 | |
| SCHEMBL10948806 | 0.75 | LMNA (0.41) | TOP1DHODHLMNA | |
| SCHEMBL597833 | 0.72 | TOP2A (0.40) | CKS1BSKP2GLO1MMP2TOP2A | |
| SCHEMBL870765 | 0.72 | TOP2A (0.40) | CKS1BSKP2GLO1MMP2TOP2A | |
| SCHEMBL7873518 | 0.71 | TOP2A (0.39) | CKS1BSKP2GLO1MMP2TOP2A | |
| SCHEMBL6037850 | 0.71 | TOP2A (0.39) | CKS1BSKP2GLO1MMP2TOP2A | |
| SCHEMBL27805381 | 0.71 | TOP2A (0.39) | CKS1BSKP2GLO1MMP2TOP2A | |
| Water SCHEMBL8819292 | 0.70 | TOP2A (0.38) | CKS1BSKP2GLO1MMP2TOP2A | |
| SCHEMBL29026621 | 0.70 | TOP2A (0.38) | CKS1BSKP2GLO1MMP2TOP2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0255534-B1 | BINDING ASSAY AND ASSAY REAGENT | CELLTECH LIMITED (GB) | 1992-04-08 | — | — | EP | disclosed |
| EP-0255534-A1 | BINDING ASSAY AND ASSAY REAGENT. | DAVIDSON ROBERT STEPHEN | 1988-02-10 | — | — | EP | disclosed |
| WO-1987004523-A1 | BINDING ASSAY AND ASSAY REAGENT | DAVIDSON ROBERT STEPHEN | 1987-07-30 | — | — | WO | disclosed |