SCHEMBL9637348

SCHEMBL9637348

ClCCCCCCOC(c1ccccc1)(c1ccccc1)c1ccccc1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KIF11 P52732 1/20 0.55
HRH4 Q9H3N8 1/20 0.46
TK2 O00142 11/20 0.46
TK1 P04183 1/20 0.43
KCNA3 P22001 1/20 0.40
DUT P33316 1/20 0.38
HDAC3 O15379 1/20 0.37
HDAC4 P56524 1/20 0.37
HDAC1 Q13547 1/20 0.37
HDAC7 Q8WUI4 1/20 0.37
HDAC2 Q92769 1/20 0.37
HDAC10 Q969S8 1/20 0.37
HDAC11 Q96DB2 1/20 0.37
HDAC8 Q9BY41 1/20 0.37
HDAC6 Q9UBN7 1/20 0.37
HDAC9 Q9UKV0 1/20 0.37
HDAC5 Q9UQL6 1/20 0.37
TSHR P16473 2/20 0.35
CYP2C9 P11712 1/20 0.35
ALOX15 P16050 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5282316 0.92 KIF11 (0.59) KIF11HRH4TK2TK1KCNA3
SCHEMBL3573169 0.84 KIF11 (0.63) KIF11HRH4TK2TK1DUT
SCHEMBL20032419 0.81 KIF11 (0.55) KIF11HRH4TK2TK1KCNA3
SCHEMBL21411547 0.81 KIF11 (0.55) KIF11HRH4TK2TK1TSHR
SCHEMBL17377651 0.81 KIF11 (0.55) KIF11HRH4TK2TK1KCNA3
SCHEMBL25077435 0.81 KIF11 (0.55) KIF11HRH4TK2TK1TSHR
SCHEMBL25077100 0.81 KIF11 (0.55) KIF11HRH4TK2TK1TSHR
SCHEMBL5820308 0.81 KIF11 (0.55) KIF11HRH4TK2TK1TSHR
SCHEMBL914263 0.81 KIF11 (0.55) KIF11HRH4TK2TK1KCNA3
SCHEMBL8703547 0.81 KIF11 (0.71) KIF11HRH4TK2TK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0290061-B1 LINEAR ADDITION POLYMER WITH HYPERPOLARIZABLE SIDE GROUPS Akzo Nobel N.V. (NL) 1992-07-15 EP disclosed
US-5043391-A Linear addition polymer with hyperpolarizable side groups AKZO N.V. (NL) 1991-08-27 US disclosed
EP-0247201-B1 PROPANE-1,3-DIOL DERIVATIVES, A METHOD FOR THEIR PRODUCTION AND A PHARMACEUTICAL COMPOSITION LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB) (DK) 1991-05-15 EP disclosed
US-4999401-A Electro-optical Laminates AKZO N.V. (NL) 1991-03-12 US disclosed
US-4945098-A Novel propane-1,3-diol derivatives and use LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB) (DK) 1990-07-31 US disclosed
US-4867516-A Electro-optically induced optical waveguide, and active devices comprising such a waveguide STAAT DER NEDERLANDEN (NL) 1989-09-19 US disclosed
EP-0290061-A1 Linear addition polymer with hyperpolarizable side groups Akzo Nobel N.V. (NL) 1988-11-09 EP disclosed
EP-0247201-A1 PROPANE-1,3-DIOL DERIVATIVES, A METHOD FOR THEIR PRODUCTION AND A PHARMACEUTICAL COMPOSITION. LEO PHARM PROD LTD (DK) 1987-12-02 EP disclosed
WO-1987003281-A1 PROPANE-1,3-DIOL DERIVATIVES, A METHOD FOR THEIR PRODUCTION AND A PHARMACEUTICAL COMPOSITION LEO PHARMACEUTICAL PRODUCTS LTD. A/S (DK) 1987-06-04 WO disclosed
US-4179451-A HYPOTENSIVE, ANTIULCER, BRONCHODILATOR, ANTICONVULSANTS OR ANTIMICROBIAL AGENTS AMERICAN CYANAMID COMPANY (US) 1979-12-18 US disclosed
US-4107441-A HYPOTENSIVE, ANTIULCER, BRONCHODILATORS, ANTIMICROBIAL, ANTICONVULSANTS AMERICAN CYANAMID COMPANY (US) 1978-08-15 US disclosed
US-4061672-A Derivatives of 9-hydroxy-13-trans-prostenoic acid AMERICAN CYANAMID COMPANY (US) 1977-12-06 US disclosed
US-3950406-A BRONCHODILATORS, HYPOTENSIVE, ANTIULCER AMERICAN CYANAMID COMPANY (US) 1976-04-13 US disclosed