Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 12/20 | 0.70 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.64 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | CASP1 | P29466 | 1/20 | 0.56 |
| ▸ | CASP7 | P55210 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | NQO2 | P16083 | 1/20 | 0.54 |
| ▸ | RELA | Q04206 | 1/20 | 0.54 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.53 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.53 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9637407 | 1.00 | APP (0.70) | APPHRH3MAPTKDM4EALDH1A1 | |
| SCHEMBL9636069 | 0.80 | APP (0.77) | APPHRH3PTGS1PTGS2ALOX5 | |
| SCHEMBL9636066 | 0.80 | APP (0.77) | APPHRH3PTGS1PTGS2ALOX5 | |
| SCHEMBL8398561 | 0.80 | APP (0.76) | APPHRH3MAPTKDM4EALDH1A1 | |
| SCHEMBL8398565 | 0.80 | APP (0.76) | APPHRH3MAPTKDM4EALDH1A1 | |
| SCHEMBL28755128 | 0.76 | RELA (0.66) | KDM4EALDH1A1HPGDTP53SMN1; SMN2 | |
| SCHEMBL10705153 | 0.76 | APP (0.57) | APPHRH3 | |
| SCHEMBL10705151 | 0.76 | APP (0.57) | APPHRH3 | |
| SCHEMBL28897947 | 0.76 | ABCG2 (0.63) | APPMAPTSMN1; SMN2LMNA | |
| SCHEMBL28897946 | 0.76 | ABCG2 (0.63) | APPMAPTSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5093505-A | Pyranone and pyran-thione derivatives | WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) | 1992-03-03 | — | — | US | disclosed |