Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 12/20 | 0.89 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9637849 | 1.00 | OPRK1 (0.89) | OPRK1OPRD1MEN1LMNAMAPK1 | |
| Fumaric Acid SCHEMBL9636739 | 0.83 | OPRK1 (0.90) | OPRK1OPRD1 | |
| Fumaric Acid SCHEMBL9636731 | 0.83 | OPRK1 (0.90) | OPRK1OPRD1 | |
| SCHEMBL9637956 | 0.83 | OPRK1 (0.78) | OPRK1OPRD1KMT2A | |
| Fumaric Acid SCHEMBL10517432 | 0.82 | OPRD1 (0.66) | OPRK1OPRD1MEN1LMNAMAPK1 | |
| Fumaric Acid SCHEMBL10517419 | 0.82 | OPRD1 (0.66) | OPRK1OPRD1MEN1LMNAMAPK1 | |
| Fumaric Acid SCHEMBL9637934 | 0.82 | OPRK1 (0.90) | OPRK1OPRD1 | |
| Fumaric Acid SCHEMBL9637939 | 0.82 | OPRK1 (0.90) | OPRK1OPRD1 | |
| SCHEMBL9636786 | 0.79 | OPRK1 (1.00) | OPRK1OPRD1 | |
| SCHEMBL9528122 | 0.78 | OPRK1 (0.71) | OPRK1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5109008-A | Analgesics, diuretics, antiischemic agents | GLAXO GROUP LIMITED (GB) | 1992-04-28 | — | — | US | disclosed |
| EP-0366327-A1 | Furo- and thieno[3,2-c]pyridines and pharmaceutical compositions containing them | GLAXO GROUP LIMITED (GB) | 1990-05-02 | — | — | EP | disclosed |