⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19827172 | 0.80 | ATM (0.50) | — | |
| SCHEMBL22997901 | 0.78 | — | — | |
| SCHEMBL3953092 | 0.76 | — | — | |
| SCHEMBL3914396 | 0.74 | — | — | |
| SCHEMBL19961477 | 0.70 | ATM (0.58) | — | |
| SCHEMBL18106186 | 0.70 | ATM (0.58) | — | |
| SCHEMBL17260754 | 0.69 | KDM4E (0.31) | — | |
| SCHEMBL23235966 | 0.69 | MEN1 (0.36) | — | |
| SCHEMBL10690731 | 0.69 | — | — | |
| SCHEMBL8538434 | 0.68 | LMNA (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12545668-B2 | Cyclic amine derivative as agent for promoting advillin function, and novel cyclic amine derivative and pharmaceutical use thereof | TORAY INDUSTRIES, INC. (JP) | 2026-02-10 | — | — | US | disclosed |
| EP-3777858-B1 | AGENT FOR INHIBITING RISE IN INTRANEURONAL CALCIUM CONCENTRATION | TORAY INDUSTRIES (JP) | 2025-04-02 | — | — | EP | disclosed |
| CN-111902143-B | Inhibitors of calcium concentration increase in nerve cells | 东丽株式会社 | 2024-01-02 | — | — | CN | disclosed |
| US-11510914-B2 | Agent for inhibiting rise in intraneuronal calcium concentration | TORAY INDUSTRIES, INC. (JP) | 2022-11-29 | — | — | US | disclosed |
| CN-115124512-A | Cyclic amine derivative and medical use thereof | 东丽株式会社 | 2022-09-30 | — | — | CN | disclosed |
| US-20220081431-A1 | CYCLIC AMINE DERIVATIVE AS AGENT FOR PROMOTING ADVILLIN FUNCTION, AND NOVEL CYCLIC AMINE DERIVATIVE AND PHARMACEUTICAL USE THEREOF | TORAY INDUSTRIES, INC. (JP) | 2022-03-17 | — | — | US | disclosed |
| US-20220081431-A1 | CYCLIC AMINE DERIVATIVE AS AGENT FOR PROMOTING ADVILLIN FUNCTION, AND NOVEL CYCLIC AMINE DERIVATIVE AND PHARMACEUTICAL USE THEREOF | TORAY INDUSTRIES, INC. (JP) | 2022-03-17 | — | — | US | disclosed |
| EP-3903784-A1 | CYCLIC AMINE DERIVATIVE AS ADVILLIN FUNCTION PROMOTER AND NOVEL CYCLIC AMINE DERIVATIVE AND PHARMACEUTICAL USE THEREOF | Toray Industries, Inc. (JP) | 2021-11-03 | — | — | EP | disclosed |
| CN-113194947-A | Cyclic amine derivatives as Advillin function promoters and novel cyclic amine derivatives and pharmaceutical use thereof | 东丽株式会社 | 2021-07-30 | — | — | CN | disclosed |
| EP-3777858-A1 | AGENT FOR INHIBITING RISE IN INTRANEURONAL CALCIUM CONCENTRATION | Toray Industries, Inc. (JP) | 2021-02-17 | — | — | EP | disclosed |
| US-20180072701-A1 | CYCLIC AMINE DERIVATIVE AND PHARMACEUTICAL USE THEREOF | TORAY INDUSTRIES, INC. (JP) | 2018-03-15 | — | — | US | disclosed |
| US-20180072701-A1 | CYCLIC AMINE DERIVATIVE AND PHARMACEUTICAL USE THEREOF | TORAY INDUSTRIES, INC. (JP) | 2018-03-15 | — | — | US | disclosed |
| US-20180072701-A1 | CYCLIC AMINE DERIVATIVE AND PHARMACEUTICAL USE THEREOF | TORAY INDUSTRIES, INC. (JP) | 2018-03-15 | — | — | US | disclosed |
| EP-3275878-A1 | CYCLIC AMINE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES | Toray Industries, Inc. (JP) | 2018-01-31 | — | — | EP | disclosed |
| EP-3275878-A1 | CYCLIC AMINE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES | Toray Industries, Inc. (JP) | 2018-01-31 | — | — | EP | disclosed |
| WO-2016152952-A1 | CYCLIC AMINE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES | 東レ株式会社 | 2016-09-29 | — | — | WO | disclosed |
| US-5147863-A | 2,2'-bi-1H-imidazoles | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-09-15 | — | — | US | disclosed |
| EP-0229922-B1 | NOVEL 2,2'-BI-1H-IMIDAZOLES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-04-15 | — | — | EP | disclosed |
| CN-86108027-A | Prepare new 2,2 '-method of Lian-1H-imidazoles | — | 1987-10-07 | — | — | CN | disclosed |
| EP-0229922-A2 | Novel 2,2'-BI-1H-imidazoles | MERRELL DOW PHARMACEUTICALS INC. (US) | 1987-07-29 | — | — | EP | disclosed |