SCHEMBL9639243

SCHEMBL9639243

COC(=O)c1cccc(I)c1O

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.55
LMNA P02545 1/20 0.55
HSD17B10 Q99714 2/20 0.48
ALDH1A1 P00352 1/20 0.48
CFTR P13569 1/20 0.48
CA1 P00915 4/20 0.48
CA2 P00918 4/20 0.48
CA9 Q16790 4/20 0.48
CA12 O43570 3/20 0.48
CA7 P43166 3/20 0.48
CA14 Q9ULX7 3/20 0.48
KDM4E B2RXH2 2/20 0.47
POLB P06746 1/20 0.47
ATM Q13315 1/20 0.47
CXCR2 P25025 1/20 0.47
L3MBTL1 Q9Y468 1/20 0.47
MAPT P10636 3/20 0.45
MITF O75030 1/20 0.45
CA5A P35218 1/20 0.43
ALOX15 P16050 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1538293 0.86 TSHR (0.65) TSHRLMNAHSD17B10ALDH1A1CFTR
SCHEMBL2148841 0.82 LMNA (0.57) TSHRLMNAHSD17B10ALDH1A1CFTR
SCHEMBL63699 0.82 TSHR (0.61) TSHRLMNAHSD17B10ALDH1A1CFTR
SCHEMBL1097335 0.81 CA1 (0.53) TSHRLMNAHSD17B10ALDH1A1CFTR
SCHEMBL1585766 0.81 LMNA (0.50) TSHRLMNAHSD17B10ALDH1A1CFTR
SCHEMBL29753082 0.81 LMNA (0.50) TSHRLMNAHSD17B10ALDH1A1CFTR
SCHEMBL30631292 0.81 CA1 (0.53) TSHRLMNAHSD17B10ALDH1A1CFTR
Benzene SCHEMBL28449714 0.80 TSHR (0.59) TSHRLMNAHSD17B10ALDH1A1CFTR
Methyl 2,3-Dihydroxybenzoate SCHEMBL433982 0.80 LMNA (0.70) TSHRLMNAHSD17B10ALDH1A1CFTR
Ammonia Solution, Strong SCHEMBL28953721 0.80 TSHR (0.59) TSHRLMNAHSD17B10ALDH1A1CFTR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12020872-B2 Stilbene and fused stilbene derivatives as solar cell dyes Ambient Photonics, Inc. (US) 2024-06-25 US disclosed
EP-3621957-B1 FUSED STILBENE DERIVATIVES AS SOLAR CELL DYES AMBIENT PHOTONICS INC (US) 2023-08-23 EP disclosed
US-11664171-B2 Stilbene and fused stilbene derivatives as solar cell dyes Ambient Photonics, Inc. (US) 2023-05-30 US disclosed
US-20230154691-A1 Stilbene and Fused Stilbene Derivatives as Solar Cell Dyes Ambient Photonics, Inc. (US) 2023-05-18 US disclosed
EP-3374354-B1 BENZOFURAN DERIVATIVES FOR THE TREATMENT OF CNS AND OTHER DISORDERS AMBIENT PHOTONICS INC (US) 2022-09-28 EP disclosed
CN-108699019-B Benzofuran derivatives useful in the treatment of central nervous system and other diseases 华纳巴布科克绿色化学学院有限公司 2022-05-10 CN disclosed
US-20210082632-A1 Stilbene and Fused Stilbene Derivatives as Solar Cell Dyes Ambient Photonics, Inc. (US) 2021-03-18 US disclosed
EP-3621957-A1 STILBENE AND FUSED STILBENE DERIVATIVES AS SOLAR CELL DYES Ambient Photonics, Inc. (US) 2020-03-18 EP disclosed
US-10590100-B2 Benzofuran derivatives for the treatment of CNS and other disorders Ambient Photonics, Inc. (US) 2020-03-17 US disclosed
US-20180346433-A1 BENZOFURAN DERIVATIVES FOR THE TREATMENT OF CNS AND OTHER DISORDERS WARNER BABCOCK INSTITUTE FOR GREEN CHEMISTRY, LLC (US) 2018-12-06 US disclosed
WO-2018208712-A1 STILBENE AND FUSED STILBENE DERIVATIVES AS SOLAR CELL DYES WARNER BABCOCK INSITUTE FOR GREEN CHEMISTRY, LLC (US) 2018-11-15 WO disclosed
CN-108699019-A Benzofuran derivatives useful in the treatment of central nervous system and other diseases 华纳巴布科克绿色化学学院有限公司 2018-10-23 CN disclosed
EP-3374354-A1 BENZOFURAN DERIVATIVES FOR THE TREATMENT OF CNS AND OTHER DISORDERS The Warner-Babcock Institute For Green Chemistry LLC (US) 2018-09-19 EP disclosed
WO-2017083488-A1 BENZOFURAN DERIVATIVES FOR THE TREATMENT OF CNS AND OTHER DISORDERS Warner Babcock Institute for Green Chemistry (US) 2017-05-18 WO disclosed
CN-105492437-A Substituted benzofuranyl and benzoxazolyl compounds and uses thereof KARYOPHARM THERAPEUTICS INC 2016-04-13 CN disclosed
EP-0287909-B1 AMYLOIDOSIS AND ALZHEIMER'S DISEASE DIAGNOSTIC ASSAY AND REAGENTS THEREFOR SALUTAR, INC. (US) 1992-09-02 EP disclosed
US-5039511-A Amyloidosis and alzheimer's disease diagnostic assay and reagents therefor SALUTAR, INC. (US) 1991-08-13 US disclosed
US-5008099-A Amyloidosis and Alzheimer's disease diagnostic assay and reagents therefor SALUTAR, INC. (US) 1991-04-16 US disclosed
US-4933156-A Amyloidosis and Alzheimer's disease diagnostic assay and reagents therefor SALUTAR, INC. (US) 1990-06-12 US disclosed
EP-0287909-A1 Amyloidosis and Alzheimer's disease diagnostic assay and reagents therefor SALUTAR, INC. (US) 1988-10-26 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10590100-B2 Benzofuran derivatives for the treatment of CNS and other disorders PMP22, CDR2, CLN6 TSHR 3571/4885LMNA 1894/4885HSD17B10 2684/4885
US-12020872-B2 Stilbene and fused stilbene derivatives as solar cell dyes FDFT1, SUN2, CDC73 TSHR 4325/4885LMNA 2379/4885HSD17B10 925/4885
US-20230154691-A1 Stilbene and Fused Stilbene Derivatives as Solar Cell Dyes FDFT1, SUN2, CDC73 TSHR 4325/4885LMNA 2379/4885HSD17B10 925/4885
US-20180346433-A1 BENZOFURAN DERIVATIVES FOR THE TREATMENT OF CNS AND OTHER DISORDERS PMP22, CDR2, CLN6 TSHR 3571/4885LMNA 1894/4885HSD17B10 2684/4885
US-11664171-B2 Stilbene and fused stilbene derivatives as solar cell dyes SUN2, FDFT1, SIK1 TSHR 4465/4885LMNA 2169/4885HSD17B10 920/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.