Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.43 |
| ▸ | METAP1 | P53582 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.37 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL788792 | 0.75 | METAP2 (0.42) | METAP2METAP1PKN1PKN2GRIN2B | |
| SCHEMBL788096 | 0.74 | METAP2 (0.43) | METAP2METAP1HSD17B10GRIN2BKDM4E | |
| SCHEMBL5349501 | 0.74 | METAP2 (0.43) | METAP2METAP1PKN1PKN2PDE10A | |
| SCHEMBL7771672 | 0.72 | METAP2 (0.42) | METAP2METAP1GRIN2BNPY5RKMT2A | |
| SCHEMBL4521139 | 0.72 | METAP2 (0.42) | METAP2METAP1PDE10AGRIN2BNPY5R | |
| SCHEMBL28203630 | 0.70 | METAP2 (0.38) | METAP2METAP1PKN1PKN2GRIN2B | |
| SCHEMBL27233072 | 0.69 | KDM4E (0.58) | METAP2METAP1MAPTRAB9AKDM4E | |
| SCHEMBL7576752 | 0.69 | METAP2 (0.42) | METAP2METAP1PKN1PKN2NPY5R | |
| SCHEMBL1907596 | 0.69 | METAP2 (0.36) | METAP2METAP1PDE10AGRIN2BNPY5R | |
| SCHEMBL19207483 | 0.69 | METAP2 (0.39) | METAP2METAP1GRIN2BNPY5RENPP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5153180-A | Used for treating aids | BURROUGHS WELLCOME CO. | 1992-10-06 | — | — | US | disclosed |
| US-4963662-A | Fluorinated nucleosides and method for treating retrovirus infections therewith | AKADEMIE DER WISSENSCHAFTEN DER DDR (DD) | 1990-10-16 | — | — | US | disclosed |