Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.52 |
| ▸ | HTR2B | P41595 | 2/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.52 |
| ▸ | DRD3 | P35462 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | MOGAT2 | Q3SYC2 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 3/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.38 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2297588 | 0.85 | RIPK1 (0.38) | HTR1AHTR2BCHRM2DRD3 | |
| SCHEMBL2295427 | 0.85 | RIPK1 (0.38) | HTR1AHTR2BCHRM2DRD3 | |
| SCHEMBL13395498 | 0.82 | HTR1A (0.48) | HTR1AHTR2BCHRM2DRD3DRD2 | |
| SCHEMBL9640858 | 0.82 | MDM2 (0.49) | HTR2BHTR2CHTR2AHSD17B2 | |
| SCHEMBL9640958 | 0.81 | TSHR (0.40) | HTR1AHTR2B | |
| SCHEMBL2296887 | 0.76 | MEN1 (0.41) | MOGAT2 | |
| SCHEMBL2294966 | 0.76 | MEN1 (0.41) | MOGAT2 | |
| SCHEMBL9641532 | 0.74 | DRD3 (0.67) | HTR1AHTR2BCHRM2DRD3DRD2 | |
| Hydrochloric Acid SCHEMBL9641236 | 0.73 | DRD3 (0.66) | HTR1AHTR2BCHRM2DRD3DRD2 | |
| SCHEMBL2295159 | 0.73 | MDM2 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0290122-B1 | MORPHOLINE DERIVATIVES AND THEIR USE | BEECHAM GROUP PLC (GB) | 1992-12-23 | — | — | EP | disclosed |
| US-5082840-A | Animal growth regulators | BEECHAM GROUP P.L.C. (GB) | 1992-01-21 | — | — | US | disclosed |
| US-4914202-A | FOR IMPROVING FEED EFFICIENCY IN LIVESTOCK | BEECHAM GROUP P.L.C. (GB) | 1990-04-03 | — | — | US | disclosed |
| EP-0290122-A1 | Morpholine derivatives and their use | BEECHAM GROUP PLC (GB) | 1988-11-09 | — | — | EP | disclosed |