SCHEMBL9640662

SCHEMBL9640662

CC(=O)Nc1cc(Cl)c(OC(F)(F)C(F)C(F)(F)F)cc1Cl

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RECQL P46063 1/20 0.63
MEN1 O00255 2/20 0.60
KMT2A Q03164 2/20 0.60
USP2 O75604 1/20 0.60
MAPT P10636 1/20 0.60
ALOX15 P16050 1/20 0.60
ALDH1A1 P00352 3/20 0.50
RORC P51449 6/20 0.48
ROCK2 O75116 1/20 0.39
POLB P06746 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
TSHR P16473 1/20 0.38
HSD17B10 Q99714 1/20 0.38
DHODH Q02127 1/20 0.38
PGK1 P00558 1/20 0.36
CA1 P00915 1/20 0.36
CA2 P00918 1/20 0.36
CA9 Q16790 1/20 0.36
CYP1A2 P05177 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16445340 0.78 KMT2A (0.76) RECQLMEN1KMT2AUSP2MAPT
SCHEMBL6904893 0.77 KMT2A (0.83) RECQLMEN1KMT2AUSP2MAPT
Lufenuron SCHEMBL29350147 0.76 KMT2A (1.00) RECQLMEN1KMT2AUSP2MAPT
Lufenuron SCHEMBL4131569 0.76 KMT2A (1.00) RECQLMEN1KMT2AUSP2MAPT
Lufenuron SCHEMBL27105 0.76 KMT2A (1.00) RECQLMEN1KMT2AUSP2MAPT
Lufenuron SCHEMBL15555900 0.76 KMT2A (1.00) RECQLMEN1KMT2AUSP2MAPT
Lufenuron SCHEMBL28709254 0.76 KMT2A (1.00) RECQLMEN1KMT2AUSP2MAPT
Lufenuron SCHEMBL29850969 0.76 KMT2A (1.00) RECQLMEN1KMT2AUSP2MAPT
SCHEMBL16445338 0.75 KMT2A (0.70) RECQLMEN1KMT2AUSP2MAPT
SCHEMBL25658878 0.75 ALDH1A1 (0.46) MEN1KMT2AMAPTALOX15ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5153224-A Insecticide or pesticide CIBA-GEIGY CORPORATION (US) 1992-10-06 US disclosed
US-5107017-A Insecticides CIBA-GEIGY CORPORATION (US) 1992-04-21 US disclosed
US-4980506-A Benzoylphenylureas CIBA-GEIGY CORPORATION (US) 1990-12-25 US disclosed
EP-0179022-B1 BENZOYLPHENYL UREAS CIBA-GEIGY AG (CH) 1990-11-07 EP disclosed
US-4798837-A Benzoylphenylureas CIBA-GEIGY CORPORATION (US) 1989-01-17 US disclosed
EP-0179022-A2 Benzoylphenyl ureas CIBA-GEIGY AG (CH) 1986-04-23 EP disclosed