Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 4/20 | 0.34 |
| ▸ | MAOA | P21397 | 4/20 | 0.33 |
| ▸ | NISCH | Q9Y2I1 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9648848 | 1.00 | CYP1A2 (0.39) | CYP1A2MAOBMAOANISCHMAPT | |
| SCHEMBL9640676 | 0.77 | CYP1A2 (0.45) | CYP1A2MAOBMAPTSLC6A2SLC6A4 | |
| SCHEMBL20833268 | 0.77 | CYP1A2 (0.45) | CYP1A2MAOBMAPTSLC6A2SLC6A4 | |
| SCHEMBL9640267 | 0.77 | CYP1A2 (0.45) | CYP1A2MAOBMAPTSLC6A2SLC6A4 | |
| SCHEMBL6535643 | 0.72 | SLC6A3 (0.49) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL16056164 | 0.71 | SLC6A2 (0.47) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL228875 | 0.64 | POLB (0.44) | FAAH | |
| SCHEMBL14764261 | 0.63 | TAAR1 (0.52) | CYP1A2MAOASLC6A2TAAR1SIGMAR1 | |
| SCHEMBL112281 | 0.63 | TAAR1 (0.52) | CYP1A2MAOASLC6A2TAAR1SIGMAR1 | |
| SCHEMBL16056788 | 0.63 | HRH3 (0.40) | SLC6A2SIGMAR1SLC6A4GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0287042-B1 | 2-SULPHINYL-ACETYL-1,3-THIAZOLIDINES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1992-09-16 | — | — | EP | disclosed |
| US-4849437-A | 2-sulphinyl-acetyl-1,3-thiazolidines, their preparation and pharmaceutical compositions | BOEHRINGER BIOCHEMIA ROBIN S.P.A. (IT) | 1989-07-18 | — | — | US | disclosed |
| EP-0287042-A1 | 2-Sulphinyl-acetyl-1,3-thiazolidines, their preparation and pharmaceutical compositions | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1988-10-19 | — | — | EP | disclosed |