Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | LMNA | P02545 | 5/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | RAF1 | P04049 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9640703 | 1.00 | SMN1; SMN2 (0.50) | SMN1; SMN2L3MBTL1ALDH1A1KMT2AMAPK1 | |
| SCHEMBL9640715 | 0.83 | KDM4E (0.46) | SMN1; SMN2L3MBTL1ALDH1A1KMT2AMAPK1 | |
| SCHEMBL9640720 | 0.83 | KDM4E (0.46) | SMN1; SMN2L3MBTL1ALDH1A1KMT2AMAPK1 | |
| SCHEMBL305927 | 0.81 | ALDH1A1 (0.44) | SMN1; SMN2L3MBTL1ALDH1A1KMT2AMAPK1 | |
| SCHEMBL305926 | 0.81 | ALDH1A1 (0.44) | SMN1; SMN2L3MBTL1ALDH1A1KMT2AMAPK1 | |
| SCHEMBL305920 | 0.79 | TSHR (0.55) | L3MBTL1ALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL306855 | 0.79 | TSHR (0.55) | L3MBTL1ALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL305921 | 0.79 | TSHR (0.55) | L3MBTL1ALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL9641254 | 0.79 | L3MBTL1 (0.66) | SMN1; SMN2L3MBTL1ALDH1A1KMT2AMAPK1 | |
| SCHEMBL8088214 | 0.79 | SMN1; SMN2 (0.71) | SMN1; SMN2L3MBTL1ALDH1A1KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0278265-B1 | 1- [(4-Morpholinyl) alkyl] -1H-indoles useful as analgesics and preparation thereof | STERLING WINTHROP INC. (US) | 1992-09-09 | — | — | EP | disclosed |
| US-5081122-A | Antiglaucoma compositions containing 4-arylcarbonyl-1-(4-morpholinyl)-lower-alkyl)-1H-indoles and method of use thereof | STERLING DRUG INC. (US) | 1992-01-14 | — | — | US | disclosed |
| US-4874761-A | ANALGESICS | STERLING DRUG INC. (US) | 1989-10-17 | — | — | US | disclosed |
| US-4840950-A | ANALGESICS | STERLING DRUG INC. (US) | 1989-06-20 | — | — | US | disclosed |