Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC25B | P30305 | 2/20 | 0.57 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.51 |
| ▸ | TUBB | P07437 | 1/20 | 0.51 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.51 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.51 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.51 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.51 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.51 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.51 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.51 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.51 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29489280 | 0.87 | GPR84 (0.77) | CDC25BGPR84MEN1MAPTKMT2A | |
| SCHEMBL8530849 | 0.87 | GPR84 (0.77) | CDC25BGPR84MEN1MAPTKMT2A | |
| SCHEMBL9450062 | 0.83 | GPR84 (0.51) | GPR84MEN1KMT2ATUBB4ATUBB | |
| SCHEMBL3943383 | 0.82 | TUBB4A (0.50) | GPR84TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL244802 | 0.82 | CDC25B (0.80) | CDC25BMEN1MAPTKMT2AHTT | |
| SCHEMBL29414437 | 0.82 | CDC25B (0.80) | CDC25BMEN1MAPTKMT2AHTT | |
| SCHEMBL9266240 | 0.81 | TUBB4A (0.59) | GPR84MAPTNPSR1TUBB4ATUBB | |
| SCHEMBL9640522 | 0.80 | TUBB4A (0.55) | GPR84MEN1MAPTKMT2ANPSR1 | |
| Hydrochloric Acid SCHEMBL27713225 | 0.80 | CDC25B (0.77) | CDC25BMEN1MAPTKMT2AHTT | |
| SCHEMBL40257 | 0.77 | NAPRT (0.52) | GPR84MAPTTUBB4ATUBBTUBA3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0278265-B1 | 1- [(4-Morpholinyl) alkyl] -1H-indoles useful as analgesics and preparation thereof | STERLING WINTHROP INC. (US) | 1992-09-09 | — | — | EP | disclosed |
| US-5081122-A | Antiglaucoma compositions containing 4-arylcarbonyl-1-(4-morpholinyl)-lower-alkyl)-1H-indoles and method of use thereof | STERLING DRUG INC. (US) | 1992-01-14 | — | — | US | disclosed |
| US-4874761-A | ANALGESICS | STERLING DRUG INC. (US) | 1989-10-17 | — | — | US | disclosed |
| US-4840950-A | ANALGESICS | STERLING DRUG INC. (US) | 1989-06-20 | — | — | US | disclosed |
| EP-0278265-A1 | 1- [(4-Morpholinyl) alkyl] -1H-indoles useful as analgesics and preparation thereof | STERLING WINTHROP INC. (US) | 1988-08-17 | — | — | EP | disclosed |