Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.64 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.60 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.60 |
| ▸ | HTR2A | P28223 | 3/20 | 0.60 |
| ▸ | TSHR | P16473 | 3/20 | 0.60 |
| ▸ | HTR1A | P08908 | 3/20 | 0.60 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.60 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.60 |
| ▸ | DRD3 | P35462 | 3/20 | 0.60 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.60 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.60 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.60 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.60 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ephedrine SCHEMBL16196643 | 0.83 | ADRA1A (0.71) | SIGMAR1ADRA1ACYP2D6CYP2C19CYP1A2 | |
| Pseudoephedrine SCHEMBL16601218 | 0.83 | ADRA1A (0.71) | SIGMAR1ADRA1ACYP2D6CYP2C19CYP1A2 | |
| SCHEMBL28002406 | 0.80 | SIGMAR1 (0.63) | SIGMAR1CYP2D6CYP1A2TSHRCYP3A4 | |
| SCHEMBL21243273 | 0.79 | SIGMAR1 (0.73) | SIGMAR1CYP2D6CYP1A2TSHRSLC6A2 | |
| SCHEMBL5270097 | 0.79 | LMNA (0.79) | SIGMAR1ADRA1ACYP2D6CYP2C19CYP1A2 | |
| SCHEMBL7637484 | 0.79 | LMNA (0.79) | SIGMAR1ADRA1ACYP2D6CYP2C19CYP1A2 | |
| SCHEMBL7785516 | 0.79 | LMNA (0.79) | SIGMAR1ADRA1ACYP2D6CYP2C19CYP1A2 | |
| SCHEMBL9322567 | 0.78 | SIGMAR1 (1.00) | SIGMAR1ADRA1ACYP2D6CYP1A2ADRA2C | |
| SCHEMBL28073509 | 0.78 | SIGMAR1 (0.72) | SIGMAR1ADRA1ACYP2D6CYP1A2ADRA2C | |
| SCHEMBL12573499 | 0.77 | ADRA1A (0.67) | ADRA1ACYP2D6CYP2C19CYP1A2ADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0290122-B1 | MORPHOLINE DERIVATIVES AND THEIR USE | BEECHAM GROUP PLC (GB) | 1992-12-23 | — | — | EP | disclosed |
| US-5082840-A | Animal growth regulators | BEECHAM GROUP P.L.C. (GB) | 1992-01-21 | — | — | US | disclosed |
| US-4914202-A | FOR IMPROVING FEED EFFICIENCY IN LIVESTOCK | BEECHAM GROUP P.L.C. (GB) | 1990-04-03 | — | — | US | disclosed |
| EP-0290122-A1 | Morpholine derivatives and their use | BEECHAM GROUP PLC (GB) | 1988-11-09 | — | — | EP | disclosed |