SCHEMBL964301

SCHEMBL964301

CC(NCCc1ccc(OCc2cccc(F)c2)cc1)C(N)=O

nearest known ligand 0.80

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
MAOB P27338 11/20 0.80
MAOA P21397 4/20 0.80
SCN9A Q15858 1/20 0.80
PARP10 Q53GL7 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL962783 0.91 MAOB (0.69) MAOBMAOASCN9APARP10
Safinamide SCHEMBL31174565 0.89 MAOB (1.00) MAOBMAOASCN9A
Safinamide SCHEMBL29358109 0.89 MAOB (1.00) MAOBMAOASCN9A
Safinamide SCHEMBL69351 0.89 MAOB (1.00) MAOBMAOASCN9A
Safinamide SCHEMBL18805068 0.89 MAOB (1.00) MAOBMAOASCN9A
Safinamide SCHEMBL69350 0.89 MAOB (1.00) MAOBMAOASCN9A
Safinamide SCHEMBL194169 0.89 MAOB (1.00) MAOBMAOASCN9A
SCHEMBL69031 0.87 MAOB (0.60) MAOBMAOASCN9A
SCHEMBL965828 0.86 MAOB (0.85) MAOBMAOASCN9APARP10
Safinamide SCHEMBL1665715 0.85 MAOB (0.92) MAOBMAOASCN9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2222290-B1 ALPHA-AMINOAMIDE DERIVATIVES FOR THE TREATMENT OF PSYCHIATRIC DISORDERS NEWRON PHARM SPA (IT) 2021-06-16 EP claimed
US-8741957-B2 Alpha-aminoamide derivatives useful in the treatment of cognitive disorders NEWRON PHARMACEUTICALS S.P.A. (IT) 2014-06-03 US claimed
US-8445539-B2 Alpha-aminoamide derivatives useful in the treatment of psychiatric disorders NEWRON PHARMACEUTICALS S.P.A. (IT) 2013-05-21 US claimed
US-20110014304-A1 ALPHA-AMINOAMIDE DERIVATIVES USEFUL IN THE TREATMENT OF PSYCHIATRIC DISORDERS NEWRON PHARMACEUTICALS S.P.A. (IT) 2011-01-20 US claimed
EP-2222290-A1 ALPHA-AMINOAMIDE DERIVATIVES USEFUL IN THE TREATMENT OF PSYCHIATRIC DISORDERS Newron Pharmaceuticals S.p.A. (IT) 2010-09-01 EP claimed
WO-2009080470-A1 ALPHA-AMINOAMIDE DERIVATIVES USEFUL IN THE TREATMENT OF PSYCHIATRIC DISORDERS NEWRON PHARMACEUTICALS S.P.A. (IT) 2009-07-02 WO claimed
EP-2222290-B1 ALPHA-AMINOAMIDE DERIVATIVES FOR THE TREATMENT OF PSYCHIATRIC DISORDERS NEWRON PHARM SPA (IT) 2021-06-16 EP disclosed
EP-2977046-A1 ALPHA-AMINOAMIDE DERIVATIVES USEFUL IN THE TREATMENT OF COGNITIVE DISORDERS Newron Pharmaceuticals S.p.A. (IT) 2016-01-27 EP disclosed
US-8741957-B2 Alpha-aminoamide derivatives useful in the treatment of cognitive disorders NEWRON PHARMACEUTICALS S.P.A. (IT) 2014-06-03 US disclosed
US-8445539-B2 Alpha-aminoamide derivatives useful in the treatment of psychiatric disorders NEWRON PHARMACEUTICALS S.P.A. (IT) 2013-05-21 US disclosed
EP-2343064-A1 Alpha-aminoamide derivatives useful in the treatment of cognitive disorders Newron Pharmaceuticals S.p.A. (IT) 2011-07-13 EP disclosed
US-20110014304-A1 ALPHA-AMINOAMIDE DERIVATIVES USEFUL IN THE TREATMENT OF PSYCHIATRIC DISORDERS NEWRON PHARMACEUTICALS S.P.A. (IT) 2011-01-20 US disclosed
EP-2222290-A1 ALPHA-AMINOAMIDE DERIVATIVES USEFUL IN THE TREATMENT OF PSYCHIATRIC DISORDERS Newron Pharmaceuticals S.p.A. (IT) 2010-09-01 EP disclosed
US-20100016437-A1 ALPHA-AMINOAMIDE DERIVATIVES USEFUL IN THE TREATMENT OF COGNITIVE DISORDERS NEWRON PHARMACEUTICALS S.P.A. (IT) 2010-01-21 US disclosed
WO-2009080470-A1 ALPHA-AMINOAMIDE DERIVATIVES USEFUL IN THE TREATMENT OF PSYCHIATRIC DISORDERS NEWRON PHARMACEUTICALS S.P.A. (IT) 2009-07-02 WO disclosed
EP-2029130-A2 ALPHA-AMINOAMIDE DERIVATIVES USEFUL IN THE TREATMENT OF COGNITIVE DISORDERS Newron Pharmaceuticals S.p.A. (IT) 2009-03-04 EP disclosed
EP-1870097-A1 Alpha-aminoamide derivatives useful in the treatment of cognitive disorders Newron Pharmaceuticals S.p.A. (IT) 2007-12-26 EP disclosed
WO-2007144153-A2 ALPHA-AMINOAMIDE DERIVATIVES USEFUL IN THE TREATMENT OF COGNITIVE DISORDERS NEWRON PHARMACEUTICALS S.P.A. (IT) 2007-12-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100016437-A1 ALPHA-AMINOAMIDE DERIVATIVES USEFUL IN THE TREATMENT OF COGNITIVE DISORDERS PSEN1, MAPT, AADAT MAOB 709/4885MAOA 506/4885SCN9A 3223/4885
US-20110014304-A1 ALPHA-AMINOAMIDE DERIVATIVES USEFUL IN THE TREATMENT OF PSYCHIATRIC DISORDERS GABBR1, GABBR2, GABRA5 MAOB 60/4885MAOA 64/4885SCN9A 1236/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.