Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 1/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | BACE1 | P56817 | 3/20 | 0.44 |
| ▸ | MAP2 | P11137 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | FABP3 | P05413 | 1/20 | 0.40 |
| ▸ | FABP4 | P15090 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10503628 | 0.80 | ABCB11 (0.64) | ABCB11PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9642959 | 0.79 | ABCB11 (0.67) | ABCB11BACE1MAP2MAPTKDM4E | |
| SCHEMBL9713764 | 0.79 | ABCB11 (0.46) | ABCB11PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9641858 | 0.76 | BACE1 (0.48) | ABCB11PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9642545 | 0.75 | ABCB11 (0.57) | ABCB11PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9643961 | 0.75 | ABCB11 (0.57) | ABCB11PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9643184 | 0.74 | MRGPRX4 (0.42) | ABCB11PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL27971141 | 0.73 | MAP2 (0.62) | MAP2MAPTKDM4ECYP1A2POLB | |
| SCHEMBL9713245 | 0.72 | ABCB11 (0.53) | ABCB11BACE1MAPTKDM4ECYP1A2 | |
| SCHEMBL29371228 | 0.72 | ABCB11 (0.73) | ABCB11BACE1MAP2MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5091558-A | Topical administeration | SYNTEX (U.S.A.) INC. (US) | 1992-02-25 | — | — | US | disclosed |
| EP-0150831-B1 | NAPHTHALENE ANTI-PSORIATIC AGENTS | SYNTEX (U.S.A.) INC. (US) | 1988-08-10 | — | — | EP | disclosed |
| EP-0150831-A2 | Naphthalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1985-08-07 | — | — | EP | disclosed |