Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | XBP1 | P17861 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | MPO | P05164 | 1/20 | 0.48 |
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL963549 | 0.79 | MGLL (0.50) | ALDH1A1CYP3A4CYP2C19CYP2C9HPGD | |
| SCHEMBL964434 | 0.78 | ALDH1A1 (0.46) | ALDH1A1CYP3A4CYP2C19SMN1; SMN2TP53 | |
| SCHEMBL30977683 | 0.77 | TP53 (0.65) | ALDH1A1CYP3A4CYP2C19SMN1; SMN2CYP2C9 | |
| SCHEMBL4455493 | 0.77 | TP53 (0.65) | ALDH1A1CYP3A4CYP2C19SMN1; SMN2CYP2C9 | |
| SCHEMBL19638004 | 0.76 | CYP3A4 (0.56) | ALDH1A1CYP3A4CYP2C19SMN1; SMN2CYP2C9 | |
| SCHEMBL11827252 | 0.75 | TP53 (0.58) | ALDH1A1CYP3A4CYP2C19SMN1; SMN2CYP2C9 | |
| SCHEMBL5558934 | 0.75 | ALDH1A1 (0.60) | ALDH1A1CYP3A4CYP2C19SMN1; SMN2CYP2C9 | |
| SCHEMBL21316522 | 0.75 | TP53 (0.58) | ALDH1A1CYP3A4CYP2C19SMN1; SMN2CYP2C9 | |
| SCHEMBL8577662 | 0.74 | HTT (0.69) | ALDH1A1CYP3A4CYP2C19SMN1; SMN2CYP2C9 | |
| SCHEMBL3460295 | 0.74 | SMN1; SMN2 (0.52) | ALDH1A1CYP3A4SMN1; SMN2CYP2C9TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070208020-A1 | P70S6 Kinase Modulators And Method Of Use | EXELIXIS, INC. | 2007-09-06 | — | — | US | claimed |
| EP-1678168-B1 | P70S6 KINASE MODULATORS AND METHOD OF USE | EXELIXIS INC (US) | 2012-07-11 | — | — | EP | disclosed |
| US-20110021525-A1 | P70S6 Kinase Modulators and Method of Use | EXELIXIS, INC. (US) | 2011-01-27 | — | — | US | disclosed |
| US-20070208020-A1 | P70S6 Kinase Modulators And Method Of Use | EXELIXIS, INC. | 2007-09-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110021525-A1 | P70S6 Kinase Modulators and Method of Use | EEF2K, RPS6KA3, MTOR | ALDH1A1 4491/4885CYP3A4 4833/4885CYP2C19 4846/4885 |
| US-20070208020-A1 | P70S6 Kinase Modulators And Method Of Use | EEF2K, RPS6KA3, MTOR | ALDH1A1 4491/4885CYP3A4 4833/4885CYP2C19 4846/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.