Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 7/20 | 0.55 |
| ▸ | G6PD | P11413 | 2/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10415704 | 0.86 | NAAA (0.48) | ALOX5G6PDALOX15ALOX12PTGS1 | |
| SCHEMBL2828339 | 0.81 | ALOX5 (0.48) | ALOX5G6PDALOX15ALOX12PTGS1 | |
| SCHEMBL10417556 | 0.78 | ALOX5 (0.46) | ALOX5G6PDALOX15ALOX12PTGS1 | |
| SCHEMBL10416816 | 0.77 | ALOX5 (0.61) | ALOX5 | |
| Phenidone SCHEMBL10904906 | 0.71 | ALOX5 (1.00) | ALOX5G6PDALOX15ALOX12PTGS1 | |
| Phenidone SCHEMBL235192 | 0.71 | ALOX5 (1.00) | ALOX5G6PDALOX15ALOX12PTGS1 | |
| Phenidone SCHEMBL8480957 | 0.69 | ALOX5 (0.96) | ALOX5G6PDALOX15ALOX12PTGS1 | |
| Phenidone SCHEMBL9281777 | 0.68 | ALOX5 (0.92) | ALOX5G6PDALOX15ALOX12PTGS1 | |
| SCHEMBL6009938 | 0.68 | ALOX5 (1.00) | ALOX5 | |
| SCHEMBL9644469 | 0.68 | ALOX5 (0.56) | ALOX5G6PDALOX15ALOX12PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5086052-A | Antiarthritic, antiallergens, antiinflammatory agents; also for asthma and psoriasis | ABBOTT LABORATORIES (US) | 1992-02-04 | — | — | US | disclosed |
| US-4970210-A | ENZYME INHIBITORS | ABBOTT LABORATORIES (US) | 1990-11-13 | — | — | US | disclosed |
| EP-0299449-A2 | Pyridazinone, triazinone and oxapyridazinone lipoxygenase inhibiting compounds | ABBOTT LABORATORIES (US) | 1989-01-18 | — | — | EP | disclosed |