SCHEMBL9645239

SCHEMBL9645239

COC(=O)C(C(=O)OC)c1cc(C)sc1C

nearest known ligand 0.46

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 1/20 0.46
ALDH1A1 P00352 5/20 0.39
SMN1; SMN2 Q16637 3/20 0.34
TSHR P16473 2/20 0.33
KMT2A Q03164 1/20 0.32
HTR1A P08908 1/20 0.32
MAPT P10636 1/20 0.32
HPGD P15428 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
GAA P10253 2/20 0.32
MAPK1 P28482 1/20 0.32
HSD17B10 Q99714 1/20 0.31
ALOX15 P16050 1/20 0.31
HTT P42858 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31
LMNA P02545 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11075312 0.87 ALOX5 (0.45) ALOX5ALDH1A1SMN1; SMN2TSHRKMT2A
SCHEMBL11083796 0.81 ALOX5 (0.43) ALOX5SMN1; SMN2KMT2AHTR1AGAA
SCHEMBL5491706 0.71 ALDH1A1 (0.42) ALDH1A1SMN1; SMN2TSHRKMT2AMAPK1
SCHEMBL22150042 0.69 ALOX5 (0.47) ALOX5ALDH1A1HTR1AGAAHTT
SCHEMBL7326998 0.69 ALOX5 (0.47) ALOX5ALDH1A1KMT2AHTR1AMAPT
SCHEMBL8542283 0.68 ALOX5 (0.46) ALOX5ALDH1A1TSHRHTR1A
SCHEMBL9645630 0.68 ALDH1A1 (0.40) ALDH1A1SMN1; SMN2TSHRKMT2AMAPT
SCHEMBL11517274 0.68 ALOX5 (0.51) ALOX5ALDH1A1KMT2AMAPTTDP1
SCHEMBL13748344 0.67 SMN1; SMN2 (0.49) ALDH1A1SMN1; SMN2TSHRKMT2AMAPT
SCHEMBL9474050 0.67 ALOX5 (0.46) ALOX5HTR1AGAAHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0506687-A1 PROCESS FOR THE PRODUCTION OF 3-THIENYL MALONIC ACID DIALKYL ESTERS HOECHST AKTIENGESELLSCHAFT (DE) 1992-10-07 EP disclosed
WO-1991009854-A1 PROCESS FOR THE PRODUCTION OF 3-THIENYL MALONIC ACID DIALKYL ESTERS HOECHST AKTIENGESELLSCHAFT (DE) 1991-07-11 WO disclosed