Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 1/20 | 0.53 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.53 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.50 |
| ▸ | G6PD | P11413 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9646977 | 0.81 | ALOX5 (0.51) | ALOX5G6PDALOX15ALOX12PTGS1 | |
| SCHEMBL16416392 | 0.74 | KMT2A (0.76) | DDB1CRBNKMT2APOLBCYP2C9 | |
| SCHEMBL29450073 | 0.74 | KMT2A (0.76) | DDB1CRBNKMT2APOLBCYP2C9 | |
| SCHEMBL11052192 | 0.74 | KMT2A (0.59) | DDB1CRBNKMT2APOLBCYP2C9 | |
| SCHEMBL5251522 | 0.73 | MAPT (0.70) | DDB1CRBNKMT2APOLBCYP2C9 | |
| SCHEMBL152680 | 0.73 | MAPT (0.70) | DDB1CRBNKMT2APOLBCYP2C9 | |
| SCHEMBL9644469 | 0.72 | ALOX5 (0.56) | ALOX5G6PDALOX15ALOX12PTGS1 | |
| SCHEMBL5642423 | 0.71 | L3MBTL1 (0.62) | DDB1CRBNKMT2APOLBCYP2C9 | |
| SCHEMBL16786536 | 0.69 | SIGMAR1 (0.58) | DDB1CRBNKMT2APOLBCYP2C9 | |
| SCHEMBL4619569 | 0.69 | SMN1; SMN2 (0.71) | DDB1CRBNKMT2APOLBCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5086052-A | Antiarthritic, antiallergens, antiinflammatory agents; also for asthma and psoriasis | ABBOTT LABORATORIES (US) | 1992-02-04 | — | — | US | disclosed |
| US-4970210-A | ENZYME INHIBITORS | ABBOTT LABORATORIES (US) | 1990-11-13 | — | — | US | disclosed |
| EP-0299449-A2 | Pyridazinone, triazinone and oxapyridazinone lipoxygenase inhibiting compounds | ABBOTT LABORATORIES (US) | 1989-01-18 | — | — | EP | disclosed |