Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 8/20 | 0.53 |
| ▸ | DRD2 | P14416 | 3/20 | 0.49 |
| ▸ | DRD3 | P35462 | 2/20 | 0.49 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.48 |
| ▸ | HTR3B | O95264 | 2/20 | 0.48 |
| ▸ | HTR3A | P46098 | 2/20 | 0.48 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.48 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.48 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11288530 | 0.89 | DRD4 (0.47) | DRD4DRD2DRD3HTR3EHTR3B | |
| SCHEMBL9645489 | 0.85 | HTR3A (0.66) | DRD2HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL11091966 | 0.82 | DRD4 (0.57) | DRD4DRD2DRD3HTR3EHTR3B | |
| SCHEMBL9645414 | 0.82 | DRD4 (0.73) | DRD4 | |
| SCHEMBL9644709 | 0.82 | DRD4 (0.67) | DRD4HTR4 | |
| SCHEMBL11456486 | 0.82 | DRD4 (0.65) | DRD4HTR4 | |
| SCHEMBL16607301 | 0.81 | ALDH1A1 (0.64) | DRD4HTR4 | |
| SCHEMBL14490802 | 0.80 | HTR3A (0.74) | DRD4DRD2DRD3HTR3EHTR3B | |
| SCHEMBL10998621 | 0.80 | DRD4 (0.63) | DRD4DRD3HTR4 | |
| SCHEMBL7406693 | 0.80 | DRD2 (0.74) | DRD4DRD2DRD3HTR3EHTR3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4213983-A | Treating gastro-intestinal disorders and emesis with n-(heterocyclic substituted) benzamides | BEECHAM GROUP LIMITED (GB) | 1980-07-22 | — | — | US | claimed |
| EP-0327335-B1 | ARYLAMIDO(AND ARYLTHIOAMIDO)-AZABICYCLOALKANES FOR ENHANCING MEMORY OR CORRECTING MEMORY DEFICIENCY | SYNTHELABO (FR) | 1992-10-14 | — | — | EP | disclosed |
| US-4863919-A | Method of enhancing memory or correcting memory deficiency with arylamido(and arylthiomido)-azabicycloalkanes | A. H. ROBINS COMPANY, INCORPORATED (US) | 1989-09-05 | — | — | US | disclosed |
| EP-0327335-A1 | Arylamido(and arylthioamido)-azabicycloalkanes for enhancing memory or correcting memory deficiency | SYNTHELABO (FR) | 1989-08-09 | — | — | EP | disclosed |
| EP-0190920-A2 | Method of enhancing memory or correcting memory deficiency with arylamido (and arylthioamido)azabicycloalkanes | SYNTHELABO (FR) | 1986-08-13 | — | — | EP | disclosed |
| US-4605652-A | ALZHEIMER'S DISEASE; SENILITY | A. H. ROBINS COMPANY, INC. (US) | 1986-08-12 | — | — | US | disclosed |
| US-4213983-A | Treating gastro-intestinal disorders and emesis with n-(heterocyclic substituted) benzamides | BEECHAM GROUP LIMITED (GB) | 1980-07-22 | — | — | US | disclosed |