Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.44 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.44 |
| ▸ | HTR3B | O95264 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | HTR3A | P46098 | 2/20 | 0.44 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.44 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7604149 | 0.75 | CRBN (0.50) | ALDH1A1KDM4ECYP1A2HSD17B10MAPK1 | |
| SCHEMBL3781498 | 0.68 | KDM4E (0.55) | ALDH1A1KDM4EHTR3EHTR3BCYP1A2 | |
| SCHEMBL9645827 | 0.68 | ALOX5 (0.54) | ALDH1A1KDM4EHTR3EHTR3BCYP1A2 | |
| SCHEMBL3798927 | 0.66 | RECQL (0.51) | ALDH1A1KDM4EHTR3EHTR3BCYP1A2 | |
| SCHEMBL10792966 | 0.64 | KMT2A (0.48) | ALDH1A1KDM4EHTR3EHTR3BCYP1A2 | |
| SCHEMBL5742495 | 0.64 | USP2 (0.48) | ALDH1A1KDM4EHTR3EHTR3BCYP1A2 | |
| SCHEMBL10609190 | 0.64 | HRH3 (0.63) | ALDH1A1KDM4EHTR3EHTR3BCYP1A2 | |
| SCHEMBL11548784 | 0.63 | HTR1A (0.51) | ALDH1A1KDM4EHTR3EHTR3BCYP1A2 | |
| SCHEMBL30046397 | 0.63 | HTR1A (0.51) | ALDH1A1KDM4EHTR3EHTR3BCYP1A2 | |
| SCHEMBL7471396 | 0.63 | ALDH1A1 (0.61) | ALDH1A1KDM4EHTR3EHTR3BCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5086052-A | Antiarthritic, antiallergens, antiinflammatory agents; also for asthma and psoriasis | ABBOTT LABORATORIES (US) | 1992-02-04 | — | — | US | disclosed |
| EP-0299449-A2 | Pyridazinone, triazinone and oxapyridazinone lipoxygenase inhibiting compounds | ABBOTT LABORATORIES (US) | 1989-01-18 | — | — | EP | disclosed |