Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.69 |
| ▸ | RAB9A | P51151 | 2/20 | 0.69 |
| ▸ | ABL1 | P00519 | 10/20 | 0.68 |
| ▸ | AR | P10275 | 1/20 | 0.63 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.62 |
| ▸ | VCP | P55072 | 1/20 | 0.62 |
| ▸ | CFTR | P13569 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1694253 | 0.84 | ABL1 (0.63) | NPC1RAB9AABL1ALOX5VCP | |
| SCHEMBL21301028 | 0.83 | NPC1 (0.58) | NPC1RAB9AABL1ARALOX5 | |
| SCHEMBL14048212 | 0.81 | NPC1 (1.00) | NPC1RAB9AABL1ARALOX5 | |
| SCHEMBL205976 | 0.81 | ALOX5 (0.80) | RAB9AABL1ALOX5VCPCFTR | |
| SCHEMBL25735740 | 0.81 | ABL1 (1.00) | NPC1RAB9AABL1MAPTKDM4E | |
| SCHEMBL18724185 | 0.78 | RAB9A (0.56) | NPC1RAB9AABL1ARALOX5 | |
| SCHEMBL1914928 | 0.78 | NPC1 (0.70) | NPC1RAB9AABL1ARALOX5 | |
| SCHEMBL1765095 | 0.78 | MAPT (0.60) | NPC1RAB9AABL1ARALOX5 | |
| SCHEMBL5698623 | 0.78 | MEN1 (0.69) | NPC1RAB9AABL1ALOX5VCP | |
| SCHEMBL8355378 | 0.78 | KDM1A (0.76) | ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8969573-B2 | Compounds for the inhibition of cellular proliferation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2015-03-03 | — | — | US | disclosed |
| US-20130178505-A1 | Compounds for the Inhibition of Cellular Proliferation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2013-07-11 | — | — | US | disclosed |
| EP-0331966-B1 | SUBSTITUTED ACRYLIC-ACID ESTERS | BAYER AG (DE) | 1992-09-23 | — | — | EP | disclosed |
| US-5120755-A | FUNGICIDAL SUBSTITUTED ACRYLIC ACID ESTERS | BAYER AKTIENGESELLSCHAFT (DE) | 1992-06-09 | — | — | US | disclosed |
| US-4968709-A | AGRICULTURE | BAYER AKTIENGESELLSCHAFT (DE) | 1990-11-06 | — | — | US | disclosed |
| EP-0331966-A1 | Substituted acrylic-acid esters | BAYER AG (DE) | 1989-09-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130178505-A1 | Compounds for the Inhibition of Cellular Proliferation | MKI67, EIF2AK2, CDK2 | NPC1 2033/4885RAB9A 3278/4885ABL1 2171/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.