Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Menthol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 known ✓ | Q7Z2W7 | 4/20 | 0.48 |
| ▸ | TRPA1 known ✓ | O75762 | 2/20 | 0.48 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Demannose SCHEMBL9474810 | 0.83 | TRPM8 (0.53) | TRPM8TRPA1EPHX1TRPV1CYP19A1 | |
| Mannitol SCHEMBL9859912 | 0.83 | TRPM8 (0.70) | TRPM8TRPA1EPHX1 | |
| Mannitol SCHEMBL28135357 | 0.83 | TRPM8 (0.70) | TRPM8TRPA1EPHX1 | |
| Demannose SCHEMBL28209682 | 0.82 | TRPM8 (0.57) | TRPM8TRPA1EPHX1TRPV1CYP19A1 | |
| SCHEMBL9648865 | 0.81 | EPHX1 (0.45) | TRPM8TRPA1EPHX1TRPV1CYP19A1 | |
| Menthol SCHEMBL18690327 | 0.80 | TRPM8 (0.70) | TRPM8TRPA1EPHX1TRPV1 | |
| SCHEMBL9617782 | 0.80 | EPHX1 (0.43) | EPHX1CYP19A1 | |
| SCHEMBL10738624 | 0.77 | PDE4A (0.45) | — | |
| SCHEMBL17144674 | 0.77 | PDE4A (0.45) | — | |
| SCHEMBL419462 | 0.77 | PDE4A (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5139034-A | Mixture of tobacco filler and menthyloxy carbonylglucose compounds | PHILIP MORRIS INCORPORATED (US) | 1992-08-18 | — | — | US | disclosed |
| EP-0486212-A2 | Smoking compositions containing a menthol-release additive | Philip Morris Products Inc. (US) | 1992-05-20 | — | — | EP | disclosed |