Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Demannose. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 known ✓ | Q7Z2W7 | 4/20 | 0.57 |
| ▸ | TRPA1 known ✓ | O75762 | 2/20 | 0.57 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.30 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.30 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Demannose SCHEMBL9474810 | 0.96 | TRPM8 (0.53) | TRPM8TRPA1EPHX1TRPV1CYP19A1 | |
| Mannitol SCHEMBL28135357 | 0.90 | TRPM8 (0.70) | TRPM8TRPA1EPHX1LMNAALDH1A1 | |
| Mannitol SCHEMBL9859912 | 0.90 | TRPM8 (0.70) | TRPM8TRPA1EPHX1LMNAALDH1A1 | |
| Menthol SCHEMBL18690327 | 0.87 | TRPM8 (0.70) | TRPM8TRPA1EPHX1LMNAALDH1A1 | |
| Menthol SCHEMBL9645923 | 0.83 | TRPM8 (0.49) | TRPM8TRPA1EPHX1LMNAALDH1A1 | |
| Menthol SCHEMBL9645915 | 0.82 | TRPM8 (0.48) | TRPM8TRPA1EPHX1TRPV1CYP19A1 | |
| Menthol SCHEMBL28240243 | 0.81 | TRPM8 (0.53) | TRPM8TRPA1EPHX1LMNATRPV1 | |
| Demannose SCHEMBL9474820 | 0.80 | EPHX1 (0.44) | EPHX1LMNAALDH1A1CYP19A1KDM4E | |
| Xylose SCHEMBL28681632 | 0.80 | ALDH1A1 (0.41) | TRPM8TRPA1EPHX1LMNAALDH1A1 | |
| Menthol SCHEMBL2311281 | 0.79 | TRPM8 (0.78) | TRPM8TRPA1EPHX1LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109385248-A | A kind of environment protection type high-strength UV glue | 深圳市泽成丰新材料有限公司 | 2019-02-26 | — | — | CN | claimed |
| CN-107006894-A | A kind of end has cigarette of oral cavity cleaning function and preparation method thereof | 安徽中烟工业有限责任公司 | 2017-08-04 | — | — | CN | claimed |
| CN-85100159-A | Cool odor precursor spice---menthol, glucose mixed carbonate manufacturing process and equipment | — | 1986-07-30 | — | — | CN | claimed |
| CN-110680019-B | Cigarette bullet for heating non-burning cigarettes | 上海龙殷生物科技有限公司 | 2024-04-09 | — | — | CN | disclosed |
| CN-112553004-B | Tobacco flavor and preparation method thereof | 湖北中烟工业有限责任公司 | 2022-06-21 | — | — | CN | disclosed |
| CN-112553004-A | Tobacco flavor and preparation method thereof | 湖北中烟工业有限责任公司 | 2021-03-26 | — | — | CN | disclosed |
| CN-110680019-A | Cigarette cartridge for heating non-combustible cigarette | 上海龙殷生物科技有限公司 | 2020-01-14 | — | — | CN | disclosed |
| CN-109385248-A | A kind of environment protection type high-strength UV glue | 深圳市泽成丰新材料有限公司 | 2019-02-26 | — | — | CN | disclosed |
| CN-108112942-A | A kind of preparation method for the nutrient buccal tablet for having the function of to prevent atrophic beriberi | 成都伤不起生物科技有限公司 | 2018-06-05 | — | — | CN | disclosed |
| CN-108094998-A | A kind of nutrient buccal tablet for having the function of to prevent memory loss | 成都伤不起生物科技有限公司 | 2018-06-01 | — | — | CN | disclosed |
| CN-107960652-A | A kind of nutrient buccal tablet for having the function of to prevent atrophic beriberi | 成都伤不起生物科技有限公司 | 2018-04-27 | — | — | CN | disclosed |
| CN-107912767-A | A kind of preparation method for the nutrient buccal tablet for having the function of to prevent memory loss | 成都伤不起生物科技有限公司 | 2018-04-17 | — | — | CN | disclosed |
| CN-107006894-A | A kind of end has cigarette of oral cavity cleaning function and preparation method thereof | 安徽中烟工业有限责任公司 | 2017-08-04 | — | — | CN | disclosed |
| CN-85100159-A | Cool odor precursor spice---menthol, glucose mixed carbonate manufacturing process and equipment | — | 1986-07-30 | — | — | CN | disclosed |
| CN-85100159-A | Cool odor precursor spice---menthol, glucose mixed carbonate manufacturing process and equipment | — | 1986-07-30 | — | — | CN | disclosed |