Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MGLL | Q99685 | 3/20 | 0.38 |
| ▸ | PPARG | P37231 | 2/20 | 0.36 |
| ▸ | NR2E3 | Q9Y5X4 | 2/20 | 0.36 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 7/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.35 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.35 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10372330 | 0.84 | ALDH1A1 (0.40) | TDP1TSHRMGLLIRAK4 | |
| SCHEMBL21565345 | 0.83 | GAA (0.41) | IRAK4CD274PDCD1LG2PDCD1 | |
| SCHEMBL21565344 | 0.83 | GAA (0.41) | IRAK4CD274PDCD1LG2PDCD1 | |
| SCHEMBL21565414 | 0.83 | GAA (0.41) | IRAK4CD274PDCD1LG2PDCD1 | |
| SCHEMBL9851967 | 0.81 | IRAK4 (0.38) | TDP1TSHRPPARGNR2E3NCOR2 | |
| SCHEMBL31124633 | 0.79 | ITGB1 (0.42) | TDP1MGLLPPARGNR2E3NCOR2 | |
| SCHEMBL4579585 | 0.79 | ITGB1 (0.42) | TDP1MGLLPPARGNR2E3NCOR2 | |
| SCHEMBL31124620 | 0.79 | ITGB1 (0.42) | TDP1MGLLPPARGNR2E3NCOR2 | |
| SCHEMBL10645217 | 0.77 | GAA (0.38) | MGLLIRAK4CD274PDCD1 | |
| SCHEMBL10650169 | 0.77 | ITGB1 (0.41) | TDP1MGLLPPARGNR2E3NCOR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0293740-B1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED LACTAMS | BASF Aktiengesellschaft (DE) | 1992-12-02 | — | — | EP | disclosed |
| EP-0238088-B1 | IMPROVED PROCESS FOR THE PREPARATION OF DIHYDRO-1H-PYRROLIZINE-3,5-(2H,6H)-DIONE | WARNER-LAMBERT COMPANY (US) | 1990-10-31 | — | — | EP | disclosed |
| US-4874865-A | Preparation of substituted lactams | BASF AKTIENGESELLSCHAFT (DE) | 1989-10-17 | — | — | US | disclosed |
| EP-0293740-A2 | Process for the preparation of substituted lactams | BASF Aktiengesellschaft (DE) | 1988-12-07 | — | — | EP | disclosed |
| EP-0095278-B1 | 5-OXO-2-PYRROLIDINEPROPANOIC ACID DERIVATIVES AND THEIR PRODUCTION | WARNER-LAMBERT COMPANY (US) | 1988-11-30 | — | — | EP | disclosed |
| EP-0238088-A2 | Improved process for the preparation of dihydro-1H-pyrrolizine-3,5-(2H,6H)-dione | WARNER-LAMBERT COMPANY (US) | 1987-09-23 | — | — | EP | disclosed |
| EP-0110575-B1 | 1-AROYL-5-OXO-2-PYRROLIDINEPROPANOIC ACIDS AND RELATED ESTERS | WARNER-LAMBERT COMPANY (US) | 1987-05-20 | — | — | EP | disclosed |
| US-4663464-A | Process for the preparation of dihydro-1H-pyrrolizine-3,5-(2H,6H)-dione | WARNER-LAMBERT COMPANY (US) | 1987-05-05 | — | — | US | disclosed |
| US-4617310-A | 5-oxo-2-pyrrolidinepropanoic acid derivatives and use as cognition activators | WARNER-LAMBERT COMPANY (US) | 1986-10-14 | — | — | US | disclosed |
| US-4559358-A | TREATING SENILITY | WARNER-LAMBERT COMPANY (US) | 1985-12-17 | — | — | US | disclosed |
| EP-0048132-B1 | THE USE OF DIHYDRO-1H-PYRROLIZINE-3,5(2H,6H)-DIONE AS A COGNITION ACTIVATOR, PHARMACEUTICAL COMPOSITIONS CONTAINING THAT COMPOUND, AND THE PRODUCTION OF SUCH COMPOSITIONS | WARNER-LAMBERT COMPANY (US) | 1984-08-15 | — | — | EP | disclosed |
| EP-0110575-A1 | 1-Aroyl-5-oxo-2-pyrrolidinepropanoic acids and related esters | WARNER-LAMBERT COMPANY (US) | 1984-06-13 | — | — | EP | disclosed |
| US-4452990-A | TREATMENT OF SENILITY, AMNESIA AND MOTIVATION | WARNER-LAMBERT COMPANY (US) | 1984-06-05 | — | — | US | disclosed |
| EP-0095278-A2 | 5-Oxo-2-pyrrolidinepropanoic acid derivatives and their production | WARNER-LAMBERT COMPANY (US) | 1983-11-30 | — | — | EP | disclosed |
| US-4372966-A | TREATMENT OF SENILITY, ENHANCING MEMORY, REVERSAL OF AMNESIA CAUSED BY ELECTRIC SHOCK | WARNER-LAMBERT COMPANY (US) | 1983-02-08 | — | — | US | disclosed |
| EP-0048132-A2 | The use of dihydro-1H-pyrrolizine-3,5(2H,6H)-dione as a cognition activator, pharmaceutical compositions containing that compound, and the production of such compositions | WARNER-LAMBERT COMPANY (US) | 1982-03-24 | — | — | EP | disclosed |