Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.45 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.45 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.45 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.44 |
| ▸ | CFTR | P13569 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31083328 | 0.85 | ALDH1A1 (0.50) | ALDH1A1GAAKDM4EGLASLC6A3 | |
| SCHEMBL2897002 | 0.84 | GAA (0.56) | ALDH1A1GAAKDM4EGLASLC6A3 | |
| SCHEMBL9303000 | 0.83 | SLC6A3 (0.61) | HSD17B10ALDH1A1GAAKDM4EGLA | |
| SCHEMBL21056695 | 0.82 | KIF11 (0.49) | ALDH1A1GAAKDM4EGLASLC6A3 | |
| SCHEMBL18566666 | 0.81 | SLC6A3 (0.68) | HSD17B10ALDH1A1GAASLC6A3CFTR | |
| SCHEMBL2898125 | 0.80 | SLC6A4 (0.51) | ALDH1A1GAAKDM4EGLACYP1A2 | |
| SCHEMBL21056912 | 0.76 | ALDH1A1 (0.53) | ALDH1A1GAAKDM4EGLASLC6A3 | |
| SCHEMBL28414807 | 0.76 | SLC6A3 (0.52) | ALDH1A1GAASLC6A3CYP1A2MAPT | |
| Hydrochloric Acid SCHEMBL4002332 | 0.76 | SLC22A12 (0.51) | ALDH1A1GAAKDM4EGLASLC6A3 | |
| SCHEMBL31584196 | 0.76 | ALDH1A1 (0.55) | ALDH1A1GAAKDM4EGLASLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1896478-B1 | Aspartyl protease inhibitors | MERCK SHARP & DOHME (US) | 2014-05-21 | — | — | EP | disclosed |
| US-7868000-B2 | Aspartyl protease inhibitors | SCHERING CORPORATION (US) | 2011-01-11 | — | — | US | disclosed |
| US-7868000-B2 | Aspartyl protease inhibitors | SCHERING CORPORATION (US) | 2011-01-11 | — | — | US | disclosed |
| US-7868000-B2 | Aspartyl protease inhibitors | SCHERING CORPORATION (US) | 2011-01-11 | — | — | US | disclosed |
| EP-1896478-A2 | ASPARTYL PROTEASE INHIBITORS | SCHERING CORPORATION (US) | 2008-03-12 | — | — | EP | disclosed |
| US-20070060575-A1 | Aspartyl protease inhibitors | MERCK SHARP & DOHME LLC | 2007-03-15 | — | — | US | disclosed |
| US-20070060575-A1 | Aspartyl protease inhibitors | MERCK SHARP & DOHME LLC | 2007-03-15 | — | — | US | disclosed |
| US-20070060575-A1 | Aspartyl protease inhibitors | MERCK SHARP & DOHME LLC | 2007-03-15 | — | — | US | disclosed |
| WO-2006138264-A2 | ASPARTYL PROTEASE INHIBITORS | SCHERING CORPORATION (US) | 2006-12-28 | — | — | WO | disclosed |
| WO-2006138264-A2 | ASPARTYL PROTEASE INHIBITORS | SCHERING CORPORATION (US) | 2006-12-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070060575-A1 | Aspartyl protease inhibitors | CHRM2, BACE1, CHRM1 | HSD17B10 2874/4885ALDH1A1 3360/4885GAA 491/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.