SCHEMBL9650469

SCHEMBL9650469

CC(C)c1c(-c2ccc(F)cc2)[c]ccc1Cl

nearest known ligand 0.31

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 1/20 0.31
KDM5B Q9UGL1 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9649272 0.83 KDM5B (0.31) KDM5B
SCHEMBL9646733 0.81 GCGR (0.31) KDM5B
SCHEMBL9650190 0.78 PDGFRB (0.33)
SCHEMBL11095391 0.77 NPC1 (0.32) PTGS2
SCHEMBL9648530 0.77 KCNH2 (0.33)
SCHEMBL9649284 0.77 CCNB2 (0.36) KDM5B
SCHEMBL9649854 0.75 PTGS2 (0.30) PTGS2
SCHEMBL6025039 0.74 CCNB2 (0.30)
SCHEMBL9649290 0.71 ACHE (0.31)
SCHEMBL9649081 0.70 GCGR (0.31)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5120848-A Anticholesterol and antilipemic agents; hydroxy-3-methylglutaryl/3-/ coenzyme A reductase inhibitors GLAXO GROUP LIMITED (GB) 1992-06-09 US disclosed