SCHEMBL9650643

SCHEMBL9650643

C=CCC(C(=O)OCC)C(=O)OC(C)(C)C

nearest known ligand 0.41

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.41
CYP2C19 P33261 2/20 0.35
CYP1A2 P05177 1/20 0.35
CYP2C9 P11712 1/20 0.35
HTT P42858 1/20 0.35
L3MBTL1 Q9Y468 3/20 0.34
MAPK1 P28482 1/20 0.34
ALDH1A1 P00352 5/20 0.33
NPSR1 Q6W5P4 1/20 0.33
LMNA P02545 3/20 0.32
MAPT P10636 1/20 0.32
IGF1R P08069 1/20 0.31
TSHR P16473 2/20 0.31
CTSK P43235 2/20 0.30
MEN1 O00255 1/20 0.30
KMT2A Q03164 1/20 0.30
TDP1 Q9NUW8 1/20 0.30
CYP3A4 P08684 1/20 0.30
HSD17B10 Q99714 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6693217 0.91 CTSK (0.34) SMN1; SMN2CYP2C19L3MBTL1LMNAMAPT
SCHEMBL793641 0.87 ALDH1A1 (0.40) SMN1; SMN2L3MBTL1MAPK1ALDH1A1NPSR1
SCHEMBL20241539 0.84 CA12 (0.35) SMN1; SMN2CYP2C19L3MBTL1ALDH1A1LMNA
SCHEMBL5082914 0.84 GRIK1 (0.35) SMN1; SMN2CYP2C19L3MBTL1MAPTTSHR
SCHEMBL31612 0.84 GRIK1 (0.35) SMN1; SMN2CYP2C19L3MBTL1MAPTTSHR
Butane SCHEMBL18797012 0.83 TSHR (0.39) SMN1; SMN2L3MBTL1MAPK1ALDH1A1NPSR1
SCHEMBL27664481 0.83 SMN1; SMN2 (0.31) SMN1; SMN2CYP2C19TSHRCTSKCYP3A4
SCHEMBL7601657 0.82 SMN1; SMN2 (0.32) SMN1; SMN2CYP2C19MAPTTSHRCTSK
SCHEMBL8183510 0.82 SMN1; SMN2 (0.32) SMN1; SMN2CYP2C19MAPTTSHRCTSK
SCHEMBL27863535 0.80 TSHR (0.44) SMN1; SMN2L3MBTL1MAPK1ALDH1A1NPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5166377-A Thromboxane A2 antagonist as coagulants or vasoconstrictors IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1992-11-24 US disclosed
US-4745198-A CARDIOVASCULAR DISORDERS, BRONCHODILATOR AGENTS IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1988-05-17 US disclosed
EP-0094239-B1 1,3-DIOXAN-5-YLALKENOIC ACIDS IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1987-07-15 EP disclosed
US-4567197-A THORMBOXANE A2 ANTAGONISTS IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1986-01-28 US disclosed
EP-0046713-B1 FLUORINATED PENTENE DIAMINE DERIVATIVES MERRELL TORAUDE ET COMPAGNIE (FR) 1985-12-27 EP disclosed
US-4439619-A Fluorinated pentene diamine derivatives MERRELL TORAUDE ET COMPAGNIE (FR) 1984-03-27 US disclosed
EP-0094239-A2 1,3-Dioxan-5-ylalkenoic acids IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1983-11-16 EP disclosed
EP-0046713-A1 Fluorinated pentene diamine derivatives MERRELL TORAUDE ET COMPAGNIE (FR) 1982-03-03 EP disclosed