Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 6/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9650689 | 0.77 | ALDH1A1 (0.45) | MEN1KMT2ACYP3A4CYP1A2CYP2C9 | |
| SCHEMBL24611536 | 0.73 | ALDH1A1 (0.45) | MEN1KMT2ACYP3A4CYP1A2CYP2C9 | |
| SCHEMBL9652626 | 0.72 | KMT2A (0.38) | ELANEMEN1KMT2ACYP3A4CYP1A2 | |
| SCHEMBL14301059 | 0.68 | ALDH1A1 (0.50) | ELANEMEN1KMT2ACYP3A4CYP1A2 | |
| SCHEMBL10939224 | 0.67 | TSHR (0.57) | ELANEMEN1KMT2ACYP3A4CYP1A2 | |
| SCHEMBL10936301 | 0.67 | ALDH1A1 (0.54) | MEN1KMT2ACYP3A4CYP1A2CYP2C9 | |
| SCHEMBL10939460 | 0.66 | CA2 (0.54) | MEN1KMT2ACYP3A4CYP1A2CYP2C9 | |
| SCHEMBL9792276 | 0.64 | ALDH1A1 (0.50) | MEN1KMT2ACYP3A4CYP1A2CYP2C9 | |
| SCHEMBL9792295 | 0.64 | MEN1 (0.50) | MEN1KMT2ACYP3A4CYP1A2CYP2C9 | |
| SCHEMBL14275900 | 0.64 | ALDH1A1 (0.45) | ELANEMEN1KMT2ACYP3A4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0480465-A2 | Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1,-dicarboxylates | SYNTEX (U.S.A.) INC. (US) | 1992-04-15 | — | — | EP | disclosed |
| US-5082950-A | Process for preparing 5-aroyl-2,3-dihydro-1H-pyrrolizine-1,1-dicarboxylates (II) and intermediates therefor | SYNTEX (U.S.A.) INC. (US) | 1992-01-21 | — | — | US | disclosed |