SCHEMBL9650808

SCHEMBL9650808

Nc1ccc(-c2ccc(-c3ccc([N+](=O)[O-])cc3)cc2)cc1

nearest known ligand 0.86

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.86
MAPT P10636 5/20 0.67
KMT2A Q03164 2/20 0.67
MEN1 O00255 1/20 0.67
LMNA P02545 1/20 0.62
CA12 O43570 3/20 0.61
CA1 P00915 3/20 0.61
CA2 P00918 3/20 0.61
CA9 Q16790 3/20 0.61
CA14 Q9ULX7 3/20 0.61
ESR1 P03372 2/20 0.56
CYP19A1 P11511 2/20 0.56
ESR2 Q92731 2/20 0.56
APP P05067 1/20 0.54
PKM P14618 1/20 0.53
TP53 P04637 1/20 0.52
CYP3A4 P08684 1/20 0.52
TDP1 Q9NUW8 1/20 0.52
MGAM O43451 1/20 0.52
GAA P10253 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL595873 1.00 ALDH1A1 (0.86) ALDH1A1MAPTKMT2AMEN1LMNA
Ammonia Solution, Strong SCHEMBL1663962 0.98 ALDH1A1 (0.82) ALDH1A1MAPTKMT2AMEN1LMNA
4-Nitroaniline SCHEMBL13529022 0.93 ALDH1A1 (1.00) ALDH1A1MAPTKMT2AMEN1LMNA
4-Nitroaniline SCHEMBL16451 0.93 ALDH1A1 (1.00) ALDH1A1MAPTKMT2AMEN1LMNA
SCHEMBL9065915 0.93 ALDH1A1 (1.00) ALDH1A1MAPTKMT2AMEN1LMNA
4-Nitroaniline SCHEMBL27963818 0.93 ALDH1A1 (1.00) ALDH1A1MAPTKMT2AMEN1LMNA
Biphenyl-4-Amine SCHEMBL27950706 0.92 ALDH1A1 (0.72) ALDH1A1MAPTKMT2AMEN1LMNA
4-Nitroaniline SCHEMBL7158091 0.90 ALDH1A1 (0.95) ALDH1A1MAPTKMT2AMEN1LMNA
4-Nitroaniline SCHEMBL21825602 0.90 ALDH1A1 (0.95) ALDH1A1MAPTKMT2AMEN1LMNA
4-Nitroaniline SCHEMBL6956705 0.90 ALDH1A1 (0.95) ALDH1A1MAPTKMT2AMEN1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5035839-A Compositions forming hydrogen bridges MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1991-07-30 US claimed
US-5139696-A Hydrogen-bonded liquid crystal complexes CORNELL RESEARCH FOUNDATION, INC. (US) 1992-08-18 US disclosed
EP-0303644-A1 HYDROGEN BOND-FORMING COMPOSITIONS MERCK PATENT GmbH (DE) 1989-02-22 EP disclosed
WO-1988006304-A1 HYDROGEN BOND-FORMING COMPOSITIONS MERCK Patent Gesellschaft mit beschränkter Haftung (DE) 1988-08-25 WO disclosed