Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA3 | P07451 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CA4 | P22748 | 1/20 | 0.44 |
| ▸ | CA6 | P23280 | 1/20 | 0.44 |
| ▸ | CA5A | P35218 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13070447 | 0.88 | NOTUM (0.53) | NOTUMLMNASMN1; SMN2MAPTKMT2A | |
| SCHEMBL3213122 | 0.88 | NOTUM (0.53) | NOTUMLMNASMN1; SMN2MAPTKMT2A | |
| Hydrochloric Acid SCHEMBL31512213 | 0.86 | NOTUM (0.51) | NOTUMLMNASMN1; SMN2MAPTKMT2A | |
| Hydrochloric Acid SCHEMBL9697361 | 0.86 | NOTUM (0.51) | NOTUMLMNASMN1; SMN2MAPTKMT2A | |
| SCHEMBL2693467 | 0.75 | LMNA (0.63) | NOTUMLMNASMN1; SMN2MAPTTDP1 | |
| SCHEMBL30958761 | 0.73 | LMNA (0.61) | NOTUMLMNASMN1; SMN2MAPTTDP1 | |
| SCHEMBL9396982 | 0.70 | GAA (0.50) | LMNASMN1; SMN2MAPTKMT2AMEN1 | |
| SCHEMBL21491851 | 0.70 | CA1 (0.56) | LMNAMAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL23084528 | 0.70 | NOTUM (0.46) | NOTUMLMNASMN1; SMN2MAPTKMT2A | |
| SCHEMBL1865732 | 0.70 | NOTUM (0.73) | NOTUMLMNASMN1; SMN2PKMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5101040-A | PROCESS FOR THE INDUSTRIAL PREPARATION OF 4-CHLORO-3-SULFAMOYL-N-(2,3-DIHYDRO-2-METHYL-1H-INDOL-1-YL)BENZAMIDE | ADIR ET COMPAGNIE (FR) | 1992-03-31 | — | — | US | disclosed |
| US-4564677-A | Preparation of N-amino compounds | USV PHARMACEUTICAL CORP. (US) | 1986-01-14 | — | — | US | disclosed |