Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.49 |
| ▸ | ADRB3 | P13945 | 5/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | THRA | P10827 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.43 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.43 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.43 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL166364 | 0.83 | ALOX15 (0.63) | ALOX15MAPTALDH1A1PPARD | |
| SCHEMBL12646485 | 0.78 | ALOX15 (0.57) | ALOX15MAPTALDH1A1PPARD | |
| Triclofenol SCHEMBL7270498 | 0.77 | HPGD (0.52) | ALOX15MAPTCA2ALDH1A1 | |
| SCHEMBL22396697 | 0.77 | MCL1 (0.68) | MCL1THRATHRBALOX15MAPT | |
| SCHEMBL1551092 | 0.75 | FFAR1 (0.72) | ALOX15MAPTPRKAG1PRKAA1PRKAB1 | |
| SCHEMBL9654642 | 0.74 | LMNA (0.48) | ADRB3ADRB1ADRB2MAPTTDP1 | |
| SCHEMBL29540672 | 0.73 | MCL1 (0.72) | MCL1ALOX15MAPTTDP1ALDH1A1 | |
| SCHEMBL118785 | 0.73 | MCL1 (0.72) | MCL1ALOX15MAPTTDP1ALDH1A1 | |
| SCHEMBL4883406 | 0.72 | PTPN7 (0.67) | MCL1ALOX15MAPTTDP1CA2 | |
| SCHEMBL339492 | 0.72 | ALOX15 (0.81) | MCL1ALOX15MAPTALDH1A1PPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0204374-B1 | TRIPEPTIDIC COMPOUNDS HAVING HYPOTENSIVE ACTIVITY | POLIFARMA S.p.A. (IT) | 1992-12-30 | — | — | EP | disclosed |
| US-5051404-A | Tripeptides of pyroglutamic acid, proline, tryptophan, phenylalanine or tyrosine and a natural aminoacid | ENIRICERCHE, S.P.A. (IT) | 1991-09-24 | — | — | US | disclosed |
| US-4810779-A | Decapeptides having hypotensive action and process for their preparation | ENICHEM ELASTOMERI S.P.A. (IT) | 1989-03-07 | — | — | US | disclosed |
| EP-0205209-A2 | Decapeptides having hypotensive action and process for their preparation | ENIRICERCHE S.p.A. (IT) | 1986-12-17 | — | — | EP | disclosed |
| EP-0204374-A2 | Tripeptidic compounds having hypotensive activity | POLIFARMA S.p.A. (IT) | 1986-12-10 | — | — | EP | disclosed |