Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 8/20 | 0.40 |
| ▸ | AGTR2 | P50052 | 7/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9657692 | 0.86 | AGTR1 (0.45) | AGTR1AGTR2 | |
| SCHEMBL9657116 | 0.83 | AGTR1 (0.43) | AGTR1AGTR2 | |
| SCHEMBL9600500 | 0.80 | AGTR2 (0.61) | AGTR1AGTR2 | |
| SCHEMBL9658510 | 0.79 | AGTR2 (0.43) | AGTR1AGTR2 | |
| SCHEMBL9658398 | 0.78 | AGTR1 (0.46) | AGTR1AGTR2 | |
| SCHEMBL9655838 | 0.76 | PPARG (0.54) | AGTR1AGTR2 | |
| SCHEMBL9657168 | 0.76 | AGTR1 (0.45) | AGTR1AGTR2 | |
| SCHEMBL9657730 | 0.76 | AGTR1 (0.43) | AGTR1AGTR2PDE10A | |
| SCHEMBL9655796 | 0.75 | AGTR1 (0.40) | AGTR1AGTR2 | |
| SCHEMBL9657164 | 0.75 | AGTR1 (0.46) | AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0510813-A1 | Angiotensin II antagonists incorporating a nitrogen containing six membered ring heterocycle | MERCK & CO. INC. (US) | 1992-10-28 | — | — | EP | claimed |
| EP-0510813-A1 | Angiotensin II antagonists incorporating a nitrogen containing six membered ring heterocycle | MERCK & CO. INC. (US) | 1992-10-28 | — | — | EP | disclosed |
| US-5128327-A | Hypotensive agents; congestive heart failure; antidepressants; anxiolytic agents; cognition activators | MERCK & CO., INC. (US) | 1992-07-07 | — | — | US | disclosed |