Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 6/20 | 0.40 |
| ▸ | AGTR2 | P50052 | 6/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9657116 | 0.90 | AGTR1 (0.43) | AGTR1AGTR2 | |
| SCHEMBL9657692 | 0.81 | AGTR1 (0.45) | AGTR1AGTR2 | |
| SCHEMBL9600500 | 0.80 | AGTR2 (0.61) | AGTR1AGTR2 | |
| SCHEMBL9658398 | 0.78 | AGTR1 (0.46) | AGTR1AGTR2PPARG | |
| SCHEMBL9657164 | 0.77 | AGTR1 (0.46) | AGTR1AGTR2 | |
| SCHEMBL9655838 | 0.77 | PPARG (0.54) | AGTR1AGTR2PPARG | |
| SCHEMBL9657168 | 0.76 | AGTR1 (0.45) | AGTR1AGTR2 | |
| SCHEMBL9655672 | 0.75 | AGTR1 (0.40) | AGTR1AGTR2 | |
| SCHEMBL9658510 | 0.75 | AGTR2 (0.43) | AGTR1AGTR2 | |
| SCHEMBL9657186 | 0.74 | PPARG (0.45) | AGTR1AGTR2PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0510813-A1 | Angiotensin II antagonists incorporating a nitrogen containing six membered ring heterocycle | MERCK & CO. INC. (US) | 1992-10-28 | — | — | EP | claimed |
| EP-0510813-A1 | Angiotensin II antagonists incorporating a nitrogen containing six membered ring heterocycle | MERCK & CO. INC. (US) | 1992-10-28 | — | — | EP | disclosed |
| US-5128327-A | Hypotensive agents; congestive heart failure; antidepressants; anxiolytic agents; cognition activators | MERCK & CO., INC. (US) | 1992-07-07 | — | — | US | disclosed |