Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.59 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.59 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.59 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.51 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methane SCHEMBL10588144 | 1.00 | PTGS1 (0.59) | PTGS1AKR1C3AKR1C2SLC2A1MTNR1A | |
| SCHEMBL9654129 | 0.99 | PTGS1 (0.60) | PTGS1AKR1C3AKR1C2SLC2A1MTNR1A | |
| Methane SCHEMBL9654134 | 0.99 | PTGS1 (0.60) | PTGS1AKR1C3AKR1C2SLC2A1MTNR1A | |
| Methane SCHEMBL9652380 | 0.90 | PTGS1 (0.65) | PTGS1AKR1C3AKR1C2MTNR1AMEN1 | |
| SCHEMBL7598913 | 0.87 | ATM (0.60) | HDAC1HDAC7POLBATMNPC1 | |
| SCHEMBL7355294 | 0.85 | MTNR1A (0.58) | MTNR1AHDAC1HDAC6ATMMTNR1B | |
| SCHEMBL7365037 | 0.82 | ATM (0.52) | POLBATMSMN1; SMN2 | |
| Methane SCHEMBL9655817 | 0.82 | PTGS1 (0.68) | PTGS1AKR1C3AKR1C2MTNR1AMEN1 | |
| SCHEMBL7357729 | 0.81 | L3MBTL1 (0.66) | KMT2AHDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL10587711 | 0.81 | PTGS1 (0.70) | PTGS1AKR1C3AKR1C2MTNR1AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0331471-B1 | HIGH MOLECULAR WEIGHT PRODRUG DERIVATIVES OF ANTIINFLAMMATORY DRUGS | Larsen, Claus Selch (DK) | 1992-12-16 | — | — | EP | disclosed |
| WO-1989008119-A1 | HIGH MOLECULAR WEIGHT PRODRUG DERIVATIVES OF ANTI-INFLAMMATORY DRUGS | SELCH LARSEN CLAUS (DK) | 1989-09-08 | — | — | WO | disclosed |
| EP-0331471-A1 | High molecular weight prodrug derivatives of antiinflammatory drugs | Larsen, Claus Selch (DK) | 1989-09-06 | — | — | EP | disclosed |