Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 10/20 | 0.43 |
| ▸ | RAB9A | P51151 | 9/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | WNT3A | P56704 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | AHR | P35869 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
| ▸ | VCP | P55072 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9656027 | 0.99 | NPC1 (0.42) | NPC1RAB9ARXFP1ALDH1A1KDM4E | |
| SCHEMBL9656920 | 0.84 | HSD11B1 (0.46) | NPC1RAB9ARXFP1ALDH1A1KDM4E | |
| SCHEMBL9656308 | 0.82 | HSD11B1 (0.47) | NPC1RAB9ARXFP1ALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL11564981 | 0.81 | ALDH1A1 (0.47) | NPC1RAB9ARXFP1ALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL9656358 | 0.76 | KDM4E (0.41) | NPC1RAB9ARXFP1ALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL9264701 | 0.75 | MAPT (0.48) | RAB9ARXFP1ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL9656933 | 0.75 | HSD11B1 (0.41) | NPC1RAB9AALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL9654561 | 0.74 | PTGS1 (0.45) | NPC1RAB9ARXFP1ALDH1A1KDM4E | |
| SCHEMBL6678346 | 0.74 | ALDH1A1 (0.64) | RAB9AALDH1A1KDM4ESMN1; SMN2HSD11B1 | |
| SCHEMBL2442712 | 0.72 | HSD11B1 (0.54) | ALDH1A1HSD11B1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0288185-B1 | THIADIAZOLE GUANIDINES | RECKITT AND COLMAN PRODUCTS LIMITED (GB) | 1992-08-19 | — | — | EP | claimed |
| US-4786627-A | ANTI-CONVULSANTS | RECKITT & COLMAN PRODUCTS LIMITED (GB) | 1988-11-22 | — | — | US | claimed |
| EP-0288185-A1 | Thiadiazole guanidines | RECKITT AND COLMAN PRODUCTS LIMITED (GB) | 1988-10-26 | — | — | EP | claimed |