Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.46 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9655057 | 0.91 | KDM4E (0.42) | KDM4ECYP1A2CYP2C9IDO1EPHX1 | |
| SCHEMBL9656780 | 0.91 | NCEH1 (0.55) | NCEH1 | |
| SCHEMBL9657078 | 0.89 | NPC1 (0.42) | KDM4ECYP1A2CYP2C9IDO1EPHX1 | |
| SCHEMBL9656357 | 0.88 | MGLL (0.54) | EPHX1NCEH1ALDH1A1 | |
| SCHEMBL9657711 | 0.87 | KDM4E (0.49) | KDM4ECYP1A2CYP2C9IDO1NCEH1 | |
| SCHEMBL9656726 | 0.86 | EPHX1 (0.44) | EPHX1NCEH1ALDH1A1MAOBPABPC1 | |
| SCHEMBL9656286 | 0.85 | EPHX1 (0.43) | EPHX1NCEH1NPC1RAB9AALDH1A1 | |
| SCHEMBL9658071 | 0.84 | NCEH1 (0.43) | EPHX1NCEH1NPC1RAB9AALDH1A1 | |
| SCHEMBL9657823 | 0.84 | MAPT (0.45) | EPHX1NCEH1 | |
| SCHEMBL9657950 | 0.83 | NCEH1 (0.45) | NCEH1NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5134161-A | Enzyme inhibitors for skin disorders, antiinflammatory agents | SYNTEX (U.S.A.) INC. (US) | 1992-07-28 | — | — | US | disclosed |
| US-4786652-A | TOPICAL ADMINISTRATION | SYNTEX (U.S.A.) INC. (US) | 1988-11-22 | — | — | US | disclosed |
| EP-0282006-A1 | Naphtalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-09-14 | — | — | EP | disclosed |