Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 10/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | BTN3A1 | O00481 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10624905 | 0.84 | SMN1; SMN2 (0.45) | FDPSSMN1; SMN2NPC1RAB9ATDP1 | |
| SCHEMBL3556536 | 0.75 | PGK1 (0.47) | SMN1; SMN2NPC1RAB9ATDP1ALDH1A1 | |
| SCHEMBL9658614 | 0.75 | FDPS (0.44) | FDPSSMN1; SMN2NPC1RAB9ATDP1 | |
| SCHEMBL1912692 | 0.72 | GAA (0.44) | SMN1; SMN2NPC1RAB9ATDP1ALDH1A1 | |
| SCHEMBL4120827 | 0.72 | PKM (0.42) | SMN1; SMN2NPC1RAB9ATDP1ALDH1A1 | |
| SCHEMBL13544288 | 0.71 | GAA (0.43) | SMN1; SMN2NPC1RAB9ATDP1ALDH1A1 | |
| SCHEMBL1107640 | 0.69 | PKM (0.48) | SMN1; SMN2NPC1RAB9ATDP1ALDH1A1 | |
| SCHEMBL9657444 | 0.69 | FDPS (0.47) | FDPSBTN3A1PDE3A | |
| SCHEMBL4134899 | 0.69 | PKM (0.45) | SMN1; SMN2NPC1RAB9ATDP1ALDH1A1 | |
| SCHEMBL10974541 | 0.69 | SMN1; SMN2 (0.53) | SMN1; SMN2NPC1RAB9ATDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0258618-B1 | DIPHOSPHONIC ACID DERIVATIVES, PROCESS FOR THEIR PREPARATION AND MEDICINES CONTAINING THOSE COMPOUNDS | Roche Diagnostics GmbH (DE) | 1992-05-06 | — | — | EP | disclosed |
| US-4777163-A | BONE DISORDERS, RHEUMATIC DISEASES | BOEHRINGER MANNHEIM GMBH (DE) | 1988-10-11 | — | — | US | disclosed |
| EP-0258618-A2 | Diphosphonic acid derivatives, process for their preparation and medicines containing those compounds | Roche Diagnostics GmbH (DE) | 1988-03-09 | — | — | EP | disclosed |