Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 10/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | DHFR | P00374 | 1/20 | 0.39 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.39 |
| ▸ | FABP3 | P05413 | 1/20 | 0.38 |
| ▸ | FABP4 | P15090 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25487575 | 0.82 | ALDH1A1 (0.51) | DHODHPDE10AALDH1A1TSHRPOLB | |
| SCHEMBL3837660 | 0.79 | P2RX7 (0.48) | DHODHPDE10AALDH1A1TSHRKMT2A | |
| SCHEMBL5215349 | 0.77 | ALDH1A1 (0.41) | ALDH1A1POLBMEN1KMT2AKDM4E | |
| SCHEMBL23858724 | 0.76 | ALDH1A1 (0.45) | DHODHALDH1A1TSHRPOLBMEN1 | |
| SCHEMBL30251746 | 0.76 | ALDH1A1 (0.45) | DHODHALDH1A1TSHRPOLBMEN1 | |
| SCHEMBL4058945 | 0.76 | ALDH1A1 (0.43) | ALDH1A1POLBKMT2AKDM4ERAB9A | |
| SCHEMBL9248212 | 0.76 | ALDH1A1 (0.43) | DHODHALDH1A1POLBKDM4ERAB9A | |
| SCHEMBL10785665 | 0.74 | P2RX7 (0.44) | ALDH1A1POLBMEN1KMT2AKDM4E | |
| SCHEMBL31556360 | 0.73 | ALDH1A1 (0.41) | ALDH1A1POLBKDM4ERAB9A | |
| SCHEMBL564237 | 0.73 | KDM4E (0.44) | ALDH1A1TSHRPOLBKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0109284-B1 | 6,7-DIHYDRO-5,8-DIMETHYL-9-FLUORO-1-OXO-1H,5H-BENZO(IJ)QUINOLIZINE-2-CARBOXYLIC ACID AND DERIVATIVES | RIKER LABORATORIES, INC. (US) | 1989-01-11 | — | — | EP | claimed |
| US-4585868-A | BACTERICIDES | RIKER LABORATORIES, INC. (US) | 1986-04-29 | — | — | US | claimed |
| EP-0109284-A1 | 6,7-Dihydro-5,8-dimethyl-9-fluoro-1-oxo-1H,5H-benzo(ij)quinolizine-2-carboxylic acid and derivatives | RIKER LABORATORIES, INC. (US) | 1984-05-23 | — | — | EP | claimed |
| EP-0245913-B1 | Process for preparing 6,7-dihydro-5,8-dimethyl-9-fluoro-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid | RIKER LABORATORIES, INC. (US) | 1992-03-25 | — | — | EP | disclosed |
| US-4898945-A | Process for 6,7-dihydro-5,8-dimethyl-9-fluoro-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1990-02-06 | — | — | US | disclosed |
| EP-0109284-B1 | 6,7-DIHYDRO-5,8-DIMETHYL-9-FLUORO-1-OXO-1H,5H-BENZO(IJ)QUINOLIZINE-2-CARBOXYLIC ACID AND DERIVATIVES | RIKER LABORATORIES, INC. (US) | 1989-01-11 | — | — | EP | disclosed |
| EP-0245913-A1 | Process for preparing 6,7-dihydro-5,8-dimethyl-9-fluoro-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid | RIKER LABORATORIES, INC. (US) | 1987-11-19 | — | — | EP | disclosed |
| EP-0079162-B1 | DERIVATIVES OF 8-AMINO AND 8-AMINOMETHYL BENZO(IJ)QUINOLIZINE | RIKER LABORATORIES, INCORPORATED (US) | 1986-07-23 | — | — | EP | disclosed |
| US-4585868-A | BACTERICIDES | RIKER LABORATORIES, INC. (US) | 1986-04-29 | — | — | US | disclosed |
| US-4585868-A | BACTERICIDES | RIKER LABORATORIES, INC. (US) | 1986-04-29 | — | — | US | disclosed |
| US-4565872-A | 5-CYANOQUINALDINE AND 6-FLUORO DERIVATIVE, MICROBIOCIDES | RIKER LABORATORIES, INC. (US) | 1986-01-21 | — | — | US | disclosed |
| US-4472405-A | Antimicrobial 6,7-dihydro-5,8-dimethyl-9 fluoro-1-oxo-1H, 5H-benzo (ij) quinolizine-2-carboxylic acid and derivatives | RIKER LABORATORIES, INC. (US) | 1984-09-18 | — | — | US | disclosed |
| EP-0109284-A1 | 6,7-Dihydro-5,8-dimethyl-9-fluoro-1-oxo-1H,5H-benzo(ij)quinolizine-2-carboxylic acid and derivatives | RIKER LABORATORIES, INC. (US) | 1984-05-23 | — | — | EP | disclosed |
| US-4404207-A | Antimicrobial 8-substituted benzo [IJ]quinolizines | RIKER LABORATORIES, INC. (US) | 1983-09-13 | — | — | US | disclosed |
| US-4400386-A | UROGENITAL DISORDERS; PLANT DISEASES | RIKER LABORATORIES, INC. (US) | 1983-08-23 | — | — | US | disclosed |
| EP-0079162-A1 | Derivatives of 8-amino and 8-aminomethyl benzo(ij)quinolizine | RIKER LABORATORIES, INCORPORATED (US) | 1983-05-18 | — | — | EP | disclosed |
| US-4380543-A | BACTERICIDES | RIKER LABORATORIES, INC. (US) | 1983-04-19 | — | — | US | disclosed |