Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25487573 | 0.84 | KMT2A (0.51) | ALDH1A1KMT2ASMN1; SMN2POLBDHODH | |
| SCHEMBL12701351 | 0.82 | ALDH1A1 (0.47) | ALDH1A1PDE10ATSHRKMT2AMAPK1 | |
| SCHEMBL9657309 | 0.82 | DHODH (0.45) | ALDH1A1PDE10ATSHRKMT2APOLB | |
| SCHEMBL3837660 | 0.82 | P2RX7 (0.48) | ALDH1A1PDE10ATSHRKMT2AMAPK1 | |
| SCHEMBL10015553 | 0.80 | LDHA (0.47) | ALDH1A1PDE10AMAPK1SMN1; SMN2L3MBTL1 | |
| SCHEMBL8571925 | 0.75 | ALDH1A1 (0.53) | ALDH1A1KMT2AOPRK1MAPK1POLB | |
| SCHEMBL4177223 | 0.75 | ALDH1A1 (0.51) | ALDH1A1TSHRKMT2AOPRK1MAPK1 | |
| SCHEMBL30050021 | 0.74 | ALDH1A1 (0.47) | ALDH1A1PDE10ATSHRKMT2ASMN1; SMN2 | |
| SCHEMBL23858593 | 0.74 | ALDH1A1 (0.47) | ALDH1A1PDE10ATSHRKMT2ASMN1; SMN2 | |
| SCHEMBL862762 | 0.74 | ALDH1A1 (0.55) | ALDH1A1TSHRKMT2AOPRK1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11655257-B2 | MK2 inhibitors, synthesis thereof, and intermediates thereto | CELGENE CAR LLC (BM) | 2023-05-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11655257-B2 | MK2 inhibitors, synthesis thereof, and intermediates thereto | WEE2, WEE1, CDK2 | ALDH1A1 3405/4885PDE10A 3323/4885TSHR 4379/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.