SCHEMBL9657351

SCHEMBL9657351

CC(=O)c1c(C)oc2ccccc12

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C19 P33261 6/20 0.63
EYA3 Q99504 3/20 0.63
CA12 O43570 2/20 0.57
CA9 Q16790 2/20 0.57
GAA P10253 1/20 0.57
CYP2C9 P11712 3/20 0.54
CASP3 P42574 1/20 0.54
SENP8 Q96LD8 1/20 0.54
SENP7 Q9BQF6 1/20 0.54
SENP6 Q9GZR1 1/20 0.54
MEN1 O00255 1/20 0.52
KMT2A Q03164 1/20 0.52
THRA P10827 1/20 0.47
THRB P10828 1/20 0.47
NPC1 O15118 1/20 0.46
RAB9A P51151 1/20 0.46
MITF O75030 1/20 0.46
LMNA P02545 1/20 0.46
MAPT P10636 1/20 0.46
HTT P42858 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15346066 0.87 CYP2C9 (0.66) CYP2C19EYA3CA12CA9GAA
SCHEMBL1398779 0.85 CYP2C19 (0.63) CYP2C19EYA3CYP2C9MEN1KMT2A
SCHEMBL4670295 0.83 CYP2C19 (0.61) CYP2C19EYA3CA12CA9CYP2C9
SCHEMBL1919253 0.83 CYP2C19 (0.61) CYP2C19EYA3CA12CA9CYP2C9
SCHEMBL20441188 0.83 CYP2C19 (0.61) CYP2C19EYA3CA12CA9CYP2C9
SCHEMBL23604030 0.81 CYP2C19 (0.59) CYP2C19EYA3CA12CA9GAA
SCHEMBL28245008 0.81 CYP2C19 (0.79) CYP2C19EYA3CYP2C9MEN1KMT2A
SCHEMBL18018241 0.80 CYP2C19 (0.61) CYP2C19EYA3GAACYP2C9MEN1
SCHEMBL24199378 0.80 CA12 (0.66) CYP2C19EYA3CA12CA9GAA
SCHEMBL3263341 0.80 CYP2C19 (0.58) CYP2C19EYA3GAACYP2C9THRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023083295-A1 ESTER DERIVATIVES OF N4-HYDROXYCYTIDINE AND USE THEREOF SUZHOU SPRING-SEA BIO-PHARMACEUTICALS CO., LTD. (CN) 2023-05-19 WO disclosed
EP-0291172-B1 KETONE DERIVATIVES GLAXO GROUP LIMITED (GB) 1992-11-19 EP disclosed
US-5084474-A Antagonist of 5-hydroxytryptamine receptors on nerves and useful for treatment of psychotic disorders, anxiety, and nausea and vomiting, compounds of imidazole GLAXO GROUP LIMITED (GB) 1992-01-28 US disclosed
US-5019586-A 5-Hydroxytryptamine Receptor Antagonists GLAXO GROUP LIMITED 1991-05-28 US disclosed
US-4918080-A ANXIOLYTIC AGENTS, ANTIEMETICS GLAXO GROUP LIMITED (GB) 1990-04-17 US disclosed
EP-0291172-A1 Ketone derivatives GLAXO GROUP LIMITED (GB) 1988-11-17 EP disclosed