Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 4/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 5/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9658201 | 0.89 | ABCB11 (0.45) | ABCB11SMN1; SMN2ALDH1A1HPGDLMNA | |
| SCHEMBL9654746 | 0.85 | ABCB11 (0.48) | ABCB11SMN1; SMN2CYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL9657686 | 0.85 | HTT (0.40) | SMN1; SMN2ALDH1A1L3MBTL1TSHRHTT | |
| SCHEMBL9658516 | 0.82 | KMT2A (0.44) | ABCB11ALDH1A1TDP1L3MBTL1TSHR | |
| SCHEMBL9659086 | 0.81 | SLC2A1 (0.41) | SMN1; SMN2ALDH1A1L3MBTL1TSHRHTT | |
| SCHEMBL9628176 | 0.81 | ABCB11 (0.56) | ABCB11SMN1; SMN2CYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL9659000 | 0.81 | ABCB11 (0.46) | ABCB11SMN1; SMN2CYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL9657939 | 0.81 | ABCB11 (0.49) | ABCB11SMN1; SMN2CYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL9656702 | 0.81 | ABCB11 (0.41) | ABCB11ALDH1A1TDP1L3MBTL1MEN1 | |
| SCHEMBL9658003 | 0.80 | SLC2A1 (0.44) | SMN1; SMN2ALDH1A1L3MBTL1TSHRHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5134161-A | Enzyme inhibitors for skin disorders, antiinflammatory agents | SYNTEX (U.S.A.) INC. (US) | 1992-07-28 | — | — | US | disclosed |
| US-4786652-A | TOPICAL ADMINISTRATION | SYNTEX (U.S.A.) INC. (US) | 1988-11-22 | — | — | US | disclosed |
| EP-0282006-A1 | Naphtalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-09-14 | — | — | EP | disclosed |