SCHEMBL9658153

SCHEMBL9658153

CCCCCCCCCCCCCCCCCCOC(=O)CCc1cc(C(C)(C)C)c(OP2Nc3ccccc3O2)c(C(C)(C)C)c1

nearest known ligand 0.38

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
CNR2 P34972 4/20 0.35
LMNA P02545 2/20 0.35
ALDH1A1 P00352 3/20 0.34
P2RY10 O00398 2/20 0.34
EPHX2 P34913 1/20 0.34
KDM4E B2RXH2 1/20 0.33
TSHR P16473 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
THRA P10827 1/20 0.33
THRB P10828 1/20 0.33
CNR1 P21554 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11326629 0.82 CNR2 (0.35) CNR2LMNAALDH1A1P2RY10EPHX2
SCHEMBL10789260 0.79 DGKA (0.40) CNR2ALDH1A1P2RY10EPHX2THRA
SCHEMBL9660329 0.78 THRA (0.35) CNR2ALDH1A1P2RY10EPHX2THRA
SCHEMBL8976831 0.77 P2RY10 (0.40) CNR2LMNAP2RY10TDP1THRA
SCHEMBL10611247 0.77 THRA (0.38) CNR2ALDH1A1P2RY10THRATHRB
SCHEMBL17171797 0.75 DGKA (0.45) CNR2ALDH1A1THRATHRBCNR1
SCHEMBL8976832 0.75 THRA (0.39) CNR2ALDH1A1P2RY10THRATHRB
SCHEMBL11569799 0.75 CNR2 (0.41) CNR2LMNAALDH1A1P2RY10EPHX2
SCHEMBL6888169 0.75 DGKA (0.42) CNR2ALDH1A1P2RY10EPHX2THRA
SCHEMBL11571509 0.75 DGKA (0.42) CNR2ALDH1A1P2RY10EPHX2THRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5075483-A Oxidation, heat, and actinic radiation resistance CIBA-GEIGY CORPORATION (US) 1991-12-24 US claimed
US-5147909-A Oxidation, heat, radiation stabilizers for polymers CIBA-GEIGY CORPORATION (US) 1992-09-15 US disclosed
EP-0473543-A2 1,3,2-Oxazaphospholidine stabilizers CIBA-GEIGY AG (CH) 1992-03-04 EP disclosed
US-5075483-A Oxidation, heat, and actinic radiation resistance CIBA-GEIGY CORPORATION (US) 1991-12-24 US disclosed