Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.45 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.40 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.40 |
| ▸ | CETP | P11597 | 1/20 | 0.40 |
| ▸ | NPY2R | P49146 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10517984 | 0.85 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2LMNAPLA2G1BATG4B | |
| SCHEMBL9847042 | 0.80 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2LMNAPLA2G1BATG4B | |
| SCHEMBL9039809 | 0.78 | BRS3 (0.47) | ALDH1A1SMN1; SMN2LMNATSHRRAB9A | |
| Hydrochloric Acid SCHEMBL9041765 | 0.77 | BRS3 (0.47) | ALDH1A1SMN1; SMN2LMNATSHRRAB9A | |
| SCHEMBL9847039 | 0.76 | LMNA (0.42) | ALDH1A1SMN1; SMN2LMNAPLA2G1BATG4B | |
| SCHEMBL9199507 | 0.76 | TSHR (0.54) | ALDH1A1SMN1; SMN2LMNATSHRRAB9A | |
| Fumaric Acid SCHEMBL9847012 | 0.75 | ALDH1A1 (0.38) | ALDH1A1SMN1; SMN2LMNAPLA2G1BATG4B | |
| SCHEMBL9209849 | 0.74 | TSHR (0.44) | ALDH1A1SMN1; SMN2TSHRRAB9AKDM4E | |
| SCHEMBL31576010 | 0.74 | TSHR (0.42) | ALDH1A1SMN1; SMN2TSHRRAB9AKDM4E | |
| SCHEMBL22189659 | 0.73 | ALDH1A1 (0.49) | ALDH1A1LMNATSHRKDM4EROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0475352-A1 | 3-(1H-Indazol-3-yl)-4-pyridinamines, a process and intermediates for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-03-18 | — | — | EP | claimed |