Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | RXRB | P28702 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9659470 | 0.92 | HDAC1 (0.42) | HDAC1HDAC8HDAC6SMN1; SMN2RXRA | |
| SCHEMBL9659384 | 0.87 | HDAC1 (0.41) | HDAC1HDAC8HDAC6SMN1; SMN2RXRA | |
| SCHEMBL9660579 | 0.86 | ALDH1A1 (0.47) | SMN1; SMN2ACHETSHRALDH1A1PGR | |
| SCHEMBL9628306 | 0.83 | HTT (0.47) | HDAC1HDAC8HDAC6RXRARXRB | |
| SCHEMBL9658045 | 0.81 | MTNR1A (0.39) | SMN1; SMN2TSHRALDH1A1PGRGAA | |
| SCHEMBL9659356 | 0.81 | HDAC1 (0.43) | HDAC1HDAC8HDAC6RXRARXRB | |
| SCHEMBL9660373 | 0.80 | HSD17B10 (0.43) | TSHRALDH1A1PGRGAAPTGS1 | |
| SCHEMBL9659170 | 0.80 | HSD17B10 (0.43) | SMN1; SMN2TSHRALDH1A1PGRGAA | |
| SCHEMBL9657946 | 0.78 | LMNA (0.40) | SMN1; SMN2TSHRALDH1A1PGRGAA | |
| SCHEMBL9657991 | 0.78 | SLC2A1 (0.44) | HDAC6THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5155132-A | Nonsteroidal antiinflammatory agents; treating psoriasis | SYNTEX (U.S.A.) INC. (US) | 1992-10-13 | — | — | US | disclosed |
| EP-0282006-A1 | Naphtalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-09-14 | — | — | EP | disclosed |
| US-4758587-A | Naphthalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-07-19 | — | — | US | disclosed |