Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.74 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.49 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.48 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.48 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.48 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.48 |
| ▸ | NOS3 | P29474 | 1/20 | 0.47 |
| ▸ | NOS2 | P35228 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | GBA1 | P04062 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9665242 | 0.83 | MAPK1 (0.70) | MAPK1CYP1A2CYP3A4MAPTLMNA | |
| SCHEMBL9077089 | 0.81 | MAPK1 (0.83) | MAPK1CYP1A2CYP3A4MAPTLMNA | |
| SCHEMBL12182431 | 0.79 | MAPK1 (0.65) | MAPK1CYP1A2CYP3A4MAPTLMNA | |
| SCHEMBL9664553 | 0.79 | RAB9A (0.69) | MAPTLMNASMN1; SMN2NPC1RAB9A | |
| SCHEMBL20095383 | 0.79 | RAB9A (0.58) | MAPTSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL22281653 | 0.78 | MAPK1 (0.63) | MAPK1CYP1A2CYP3A4MAPTLMNA | |
| SCHEMBL8797441 | 0.78 | MAPK1 (0.63) | MAPK1CYP1A2CYP3A4MAPTLMNA | |
| SCHEMBL8798095 | 0.77 | MAPK1 (0.70) | MAPK1CYP1A2CYP3A4MAPTLMNA | |
| SCHEMBL9080445 | 0.77 | MAPK1 (0.62) | MAPK1CYP1A2CYP3A4MAPTLMNA | |
| SCHEMBL8673571 | 0.76 | SMN1; SMN2 (0.52) | MAPK1CYP1A2CYP3A4MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519996-A1 | IMIDAZOLES | RHONE-POULENC RORER LIMITED (GB) | 1992-12-30 | — | — | EP | disclosed |
| WO-1991013876-A1 | IMIDAZOLES | RHONE-POULENC RORER LIMITED (GB) | 1991-09-19 | — | — | WO | disclosed |