Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11570784 | 0.74 | POLB (0.50) | POLBLMNAHDAC3CA12CA1 | |
| SCHEMBL10616144 | 0.74 | HDAC3 (0.54) | POLBLMNAHDAC3CA12CA1 | |
| SCHEMBL9491963 | 0.72 | HDAC3 (0.52) | POLBLMNAHDAC3CA12CA1 | |
| SCHEMBL28646933 | 0.69 | ALOX15 (0.58) | POLBHDAC3CA12CA1IDO1 | |
| SCHEMBL9561167 | 0.68 | POLB (0.47) | POLBLMNAHDAC3CA12CA1 | |
| SCHEMBL7525213 | 0.68 | POLB (0.51) | POLBLMNAHDAC3CA12CA1 | |
| SCHEMBL13416406 | 0.68 | ALOX15 (0.56) | POLBHDAC3CA12CA1IDO1 | |
| SCHEMBL1233442 | 0.67 | POLB (0.59) | POLBLMNAHDAC3CA12CA1 | |
| SCHEMBL408310 | 0.66 | CYP2C9 (0.67) | POLBLMNAHDAC3CA12CA1 | |
| SCHEMBL452998 | 0.66 | ALOX15 (0.54) | POLBHDAC3CA12CA1IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0485026-A2 | Antimanic phenoxymethylene bisphosphonate derivatives | MERCK SHARP & DOHME LTD. (GB) | 1992-05-13 | — | — | EP | disclosed |