Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.60 |
| ▸ | GAA | P10253 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | TLR4 | O00206 | 1/20 | 0.49 |
| ▸ | TLR2 | O60603 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5407816 | 0.79 | LMNA (0.64) | LMNAGAAKMT2AALDH1A1HPGD | |
| SCHEMBL9378896 | 0.78 | LMNA (0.53) | LMNAGAAKMT2AALDH1A1HPGD | |
| SCHEMBL9064363 | 0.77 | LMNA (0.67) | LMNAGAAKMT2AALDH1A1HPGD | |
| SCHEMBL1157682 | 0.77 | NFE2L2 (0.53) | LMNAKMT2AALDH1A1HPGDCYP1A2 | |
| SCHEMBL5943455 | 0.77 | LMNA (0.67) | LMNAGAAKMT2AALDH1A1HPGD | |
| SCHEMBL23037109 | 0.76 | HTT (0.61) | LMNAGAAKMT2AALDH1A1HPGD | |
| SCHEMBL27645164 | 0.76 | LMNA (0.60) | LMNAGAAKMT2AALDH1A1HPGD | |
| SCHEMBL23037108 | 0.76 | HTT (0.61) | LMNAGAAKMT2AALDH1A1HPGD | |
| SCHEMBL298766 | 0.75 | LMNA (0.64) | LMNAGAAKMT2AALDH1A1HPGD | |
| SCHEMBL95238 | 0.75 | LMNA (1.00) | LMNAGAAKMT2AALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0485026-A2 | Antimanic phenoxymethylene bisphosphonate derivatives | MERCK SHARP & DOHME LTD. (GB) | 1992-05-13 | — | — | EP | disclosed |