Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD3 | Q15059 | 1/20 | 0.65 |
| ▸ | HTR7 | P34969 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | RB1 | P06400 | 7/20 | 0.57 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.57 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.57 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.50 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.47 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9610870 | 1.00 | BRD3 (0.65) | BRD3HTR7CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL9610867 | 1.00 | BRD3 (0.65) | BRD3HTR7CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL11823184 | 0.83 | DRD2 (0.58) | HTR7CYP3A4CYP2D6CYP2C19ADRA1D | |
| SCHEMBL18648563 | 0.83 | BRD3 (0.52) | BRD3HTR7CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL4151748 | 0.83 | CYP2D6 (0.66) | BRD3CYP2D6SIRT1 | |
| SCHEMBL5259416 | 0.81 | HTR7 (0.67) | BRD3HTR7RB1SIRT1ABCB1 | |
| SCHEMBL8503944 | 0.80 | HTR7 (0.62) | BRD3HTR7CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL16926961 | 0.79 | BRD3 (0.58) | BRD3HTR7CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL5254390 | 0.79 | BRD3 (0.58) | BRD3HTR7RB1SIRT1SIRT2 | |
| SCHEMBL1877922 | 0.79 | BRD3 (0.67) | BRD3HTR7CYP3A4CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0073849-A1 | Novel phenyl-1,2,3,4-tetrahydrocarbazoles, their preparation and pharmaceutical compositions containing them | SCHERING CORPORATION (US) | 1983-03-16 | — | — | EP | claimed |
| EP-0376155-B1 | N-PYRIDINYL-9H-CARBAZOL-9-AMINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-08-05 | — | — | EP | disclosed |
| EP-0073849-A1 | Novel phenyl-1,2,3,4-tetrahydrocarbazoles, their preparation and pharmaceutical compositions containing them | SCHERING CORPORATION (US) | 1983-03-16 | — | — | EP | disclosed |
| EP-0073849-A1 | Novel phenyl-1,2,3,4-tetrahydrocarbazoles, their preparation and pharmaceutical compositions containing them | SCHERING CORPORATION (US) | 1983-03-16 | — | — | EP | disclosed |
| EP-0073849-A1 | Novel phenyl-1,2,3,4-tetrahydrocarbazoles, their preparation and pharmaceutical compositions containing them | SCHERING CORPORATION (US) | 1983-03-16 | — | — | EP | disclosed |
| US-4292323-A | Phenyl-1,2,3,4-tetrahydrocarbazoles and use thereof | SCHERING CORPORATION (US) | 1981-09-29 | — | — | US | disclosed |
| US-4292323-A | Phenyl-1,2,3,4-tetrahydrocarbazoles and use thereof | SCHERING CORPORATION (US) | 1981-09-29 | — | — | US | disclosed |